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Acyl-CoA 6-desaturase Antibodies
AND FADS2 ELISA kits, Acyl-CoA 6-desaturase Proteins
Many biological assays use antibodies to detect Acyl-CoA 6-desaturase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acyl-CoA 6-desaturase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acyl-CoA 6-desaturase antibodies...
Designing a Western blot for Acyl-CoA 6-desaturase? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FADS2 Western Blot GuideDesigning an IHC experiment for Acyl-CoA 6-desaturase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the FADS2 IHC GuideFADS2 Infographic by Boster Bio
All FADS2 Products
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FADS2 Overview
Facts about Acyl-CoA 6-desaturase.
Acyl-CoA 6-desaturase (FADS2)
Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) lipoic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) to gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps.
Highly unsaturated fatty acids (HUFA) play critical roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.
Gene Information
| Human | |
|---|---|
| Gene Name: | FADS2 |
| Uniprot: | O95864 |
| Entrez: | 9415 |
Family
| Belongs to: |
|---|
| fatty acid desaturase type 1 family |
Alternative Names
D6DLLCDL2; Delta(6) desaturase; Delta(6) fatty acid desaturase; Delta-6 desaturase; delta-6 fatty acid desaturase; delta-6-desaturase; DES6; EC 1.14.19; EC 1.14.19.-; FADSD6; fatty acid desaturase 2; linoleoyl-CoA desaturase (delta-6-desaturase)-like 2; SLL0262; TU13
Molecular Weight
Mass (kDA):
52.259 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.2 |
| Sequence: | 11; NC_000011.10 (61816203..61867354) |
Tissue Specificity
Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic index.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Inflammation
- Cardiovascular Diseases
- Dysequilibrium Syndrome
- Insulin Resistance
- Obesity
- Malignant Neoplasms
- Diabetes Mellitus
- Eczema
- Dyslipidemias
- Heart Diseases
- Coronary Artery Disease
- Dermatitis, Atopic
- Arthritis
Pathways
- Lactation
- Methylation
- Transport
- Localization
- Pathogenesis
- Brain Development
- Gluconeogenesis
- Lipid Homeostasis
- Cognition
- Secretion
- Gene Silencing
- Fatty Acid Elongation
- Aging
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FADS2
bosterbio.com/bosterbio-gene-info-cards/FADS2
References
PMID: 9867867 by Cho H.P., et al. Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
PMID: 10860662 by Marquardt A., et al. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.