Folliculin Antibodies

AND FLCN ELISA kits, Folliculin Proteins

Many biological assays use antibodies to detect Folliculin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Folliculin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Folliculin antibodies...

We validate the specificity of these antibodies to Folliculin by testing them on tissues known to express FLCN positively and negatively. Browse below to find the FLCN antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Folliculin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the FLCN Western Blot Guide

FLCN Infographic by Boster Bio

All FLCN Products

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Product

Figures

Specificity

Applications

Price

Anti-FLCN Picoband® Antibody

Flow Cytometry analysis of U937 cells using anti-FLCN antibody (A00718-1)

IHC analysis of FLCN using anti-FLCN antibody (A00718-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00718-1
100 μg/vial

Anti-MUC5B Antibody

Human

ELISA, IHC

$370
Cat # A00719-2
100 μg/vial

FLCN (NM_144606) Human Over-expression Lysate

FLCN Human Over-expression Lysates NM_144606

Human

$628
Cat # LS201163
20 µg, 100 µg

Anti-FLCN Antibody (Monoclonal, 32F42)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00718
100 μl/vial

FLCN Overview

Facts about Folliculin.

FLCN 3D structure. Source: alphafold

Folliculin (FLCN)

May be a tumor suppressor. May be involved in nutrient or energy sensing through the AMPK and mTOR signaling pathways.

May regulate phosphorylation of RPS6KB1. .

Gene Information

Human
Gene Name:	FLCN
Uniprot:	Q8NFG4
Entrez:	201163

Family

Belongs to:

folliculin family

Alternative Names

BHD skin lesion fibrofolliculoma protein; BHDFLCL; Birt-Hogg-Dube syndrome protein; DKFZp547A118; FLJ45004; FLJ99377; folliculin; MGC17998; MGC23445

Molecular Weight

Mass (kDA):
64.473 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (17206946..17237188, complement)

Tissue Specificity

Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach.

Subcellular Localizations

Cytoplasm. Nucleus. Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.

Diseases

Kidney Neoplasm
Neoplasms
Multiple Fibrofolliculomas
Malignant Neoplasms
Renal Cell Carcinoma
Carcinoma
Malignant Neoplasm Of Kidney
Spontaneous Pneumothorax
Skin Diseases, Genetic
Skin Neoplasms
Lung Diseases
Neoplastic Syndromes, Hereditary

Von Hippel-lindau Syndrome
Oncocytic Neoplasm
Germline Mutation Abnormality
Hamartoma
Dermatologic Disorders
Chromophobe Renal Cell Carcinoma
Tuberous Sclerosis

Interacting Proteins

FNIP1

Pathways

Pathogenesis
Oxidative Phosphorylation
Localization
Methylation
Tricarboxylic Acid Cycle
Cell Death
Cell Adhesion
Cell Migration
Cell Proliferation
Induction Of Apoptosis
Aging
Stem Cell Maintenance
Amino Acid Homeostasis

Cytokinesis
Mismatch Repair
Dna Replication
Cell Cycle
Interphase
Angiogenesis
Glycolysis

PTMs

Phosphorylation

Methylation

Carboxylation

Research Areas

Cancer
Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLCN

References

PMID: 12204536 by Nickerson M.L., et al. Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg- Dube syndrome.

PMID: 12843323 by Kahnoski K., et al. Alterations of the Birt-Hogg-Dube gene (BHD) in sporadic colorectal tumours.