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- Table of Contents
Hexokinase-4 Antibodies
AND GCK ELISA kits, Hexokinase-4 Proteins
Many biological assays use antibodies to detect Hexokinase-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hexokinase-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hexokinase-4 antibodies...
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GCK Infographic by Boster Bio
All GCK Products
Product
Figures
Specificity
Applications
Price
Anti-Glucokinase/GCK Antibody Picoband®
2 Citations 7 Q&As
Human, Mouse, Rat
ELISA, IF, ICC, WB
$370
Cat # A00884-1
100 μg/vial
Cat # A00884-1
100 μg/vial
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M00884-1
100 µl
Cat # M00884-1
100 µl
GCK Overview
Facts about Hexokinase-4.
Hexokinase-4 (GCK)
Catalyzes the first step in utilization of glucose from the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and therefore it's effective only when glucose is abundant.
The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion.
Gene Information
| Human | |
|---|---|
| Gene Name: | GCK |
| Uniprot: | P35557 |
| Entrez: | 2645 |
Family
| Belongs to: |
|---|
| hexokinase family |
Alternative Names
EC 2.7.1; EC 2.7.1.2; FGQTL3; GCK; GK; GLK; glucokinase (hexokinase 4); Glucokinase; Hexokinase-4; Hexokinase-D; HHF3; HK4; HK4pancreatic isozyme; HKIV; HXKP; LGLK; maturity onset diabetes of the young 2; MODY2
Molecular Weight
Mass (kDA):
52.191 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p13 |
| Sequence: | 7; NC_000007.14 (44143213..44189439, complement) |
Tissue Specificity
Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
Subcellular Localizations
Cytoplasm. Nucleus. Mitochondrion. Under low glucose concentrations, GCK associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus.
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Hyperglycemia
- Maturity Onset Diabetes Mellitus In Young
- Insulin Resistance
- Hypoglycemia
- Diabetes Mellitus, Insulin-dependent
- Impaired Glucose Tolerance
- Hyperinsulinism
- Obesity
- Persistent Hyperinsulinemia Hypoglycemia Of Infancy
- Gestational Diabetes
Interacting Proteins
- GCKR
- PFKFB1
Pathways
- Secretion
- Insulin Secretion
- Glucose Homeostasis
- Pathogenesis
- Glycolysis
- Localization
- Rna Interference
- Transport
- Methylation
- Translation
- Cell Death
- Cell Proliferation
- Aging
PTMs
- Phosphorylation
- Carboxylation
- Methylation
- Nitrosylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GCK
bosterbio.com/bosterbio-gene-info-cards/GCK
References
PMID: 1354840 by Tanizawa Y., et al. Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism.
PMID: 1871135 by Tanizawa Y., et al. Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs.