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- Table of Contents
Facts about Growth/differentiation factor 9.
Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It modulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells.
Human | |
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Gene Name: | GDF9 |
Uniprot: | O60383 |
Entrez: | 2661 |
Belongs to: |
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TGF-beta family |
GDF9; GDF-9; growth differentiation factor 9; growth/differentiation factor 9
Mass (kDA):
51.444 kDA
Human | |
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Location: | 5q31.1 |
Sequence: | 5; NC_000005.10 (132861181..132866884, complement) |
Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).
Secreted.
PMID: 10443672 by Aaltonen J., et al. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.
PMID: 12050262 by Yamamoto N., et al. Growth differentiation factor-9 inhibits 3'5'-adenosine monophosphate-stimulated steroidogenesis in human granulosa and theca cells.