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- Table of Contents
GFRA2 Antibodies
AND GFRA2 ELISA kits, GFRA2 Proteins
Many biological assays use antibodies to detect GFRA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GFRA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GFRA2 antibodies...
Designing an IHC experiment for GFRA2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the GFRA2 IHC GuideGFRA2 Infographic by Boster Bio
All GFRA2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A06103-2
100 μg/vial
Cat # A06103-2
100 μg/vial
Human
$628
Cat # LS002675
20 µg, 100 µg
Cat # LS002675
20 µg, 100 µg
GFRA2 Overview
Facts about GDNF family receptor alpha-2.
GDNF family receptor alpha-2 (GFRA2)
Receptor for neurturin.
Mediates the NRTN-induced autophosphorylation and activation of the RET receptor.Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. .
Gene Information
| Human | |
|---|---|
| Gene Name: | GFRA2 |
| Uniprot: | O00451 |
| Entrez: | 2675 |
Family
| Belongs to: |
|---|
| GDNFR family |
Alternative Names
GDNF family receptor alpha 2; GDNF family receptor alpha-2; GDNF R alpha-2; GDNF receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GDNFRBRET ligand 2; GFR alpha2; GFR alpha-2; GFRA2; GFRa-2; GFR-alpha 2; GFR-alpha-2; glial cell line derived neurotrophic factor receptor, beta; Neurturin receptor alpha; NRTNR-alpha; NTNRA; NTNR-alpha; PI-linked cell-surface accessory protein; RETL2TGF-beta-related neurotrophic factor receptor 2; TGF-beta related neurotrophic factor receptor 2; TRN receptor, GPI-anchored; TRNR2NRTNR-ALPHA
Molecular Weight
Mass (kDA):
51.544 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.3 |
| Sequence: | 8; NC_000008.11 (21690398..21789296, complement) |
Tissue Specificity
Isoform 1 is found in both brain and placenta.
Subcellular Localizations
Cell membrane; Lipid-anchor, GPI-anchor.
Diseases
- Nervousness
- Neoplasms
- Pituitary Diseases
- Thyroid Neoplasm
- Nerve Damage
- Malignant Neoplasm Of Thyroid
- Malnutrition
- Carcinoma
- Pain
- Ischemia
- Epilepsy
- Malignant Neoplasms
Pathways
- Innervation
- Localization
- Regeneration
- Cell Death
- System Development
- Nervous System Development
- Secretion
- Programmed Cell Death
- Enteric Nervous System Development
- Pathogenesis
- Cell Adhesion
- Cell Proliferation
- Cell Activation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GFRA2
bosterbio.com/bosterbio-gene-info-cards/GFRA2
References
PMID: 9182803 by Baloh R.H., et al. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.
PMID: 9259272 by Suvanto P., et al. Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha.