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- Table of Contents
Facts about GDNF family receptor alpha-2.
Receptor for neurturin.
Mediates the NRTN-induced autophosphorylation and activation of the RET receptor.Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. .
Human | |
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Gene Name: | GFRA2 |
Uniprot: | O00451 |
Entrez: | 2675 |
Belongs to: |
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GDNFR family |
GDNF family receptor alpha 2; GDNF family receptor alpha-2; GDNF R alpha-2; GDNF receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GDNFRBRET ligand 2; GFR alpha2; GFR alpha-2; GFRA2; GFRa-2; GFR-alpha 2; GFR-alpha-2; glial cell line derived neurotrophic factor receptor, beta; Neurturin receptor alpha; NRTNR-alpha; NTNRA; NTNR-alpha; PI-linked cell-surface accessory protein; RETL2TGF-beta-related neurotrophic factor receptor 2; TGF-beta related neurotrophic factor receptor 2; TRN receptor, GPI-anchored; TRNR2NRTNR-ALPHA
Mass (kDA):
51.544 kDA
Human | |
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Location: | 8p21.3 |
Sequence: | 8; NC_000008.11 (21690398..21789296, complement) |
Isoform 1 is found in both brain and placenta.
Cell membrane; Lipid-anchor, GPI-anchor.
This article will help you optimize your experiments using the GFRA2 marker. This article will cover Boster Bio's GFRA2 marker, High-affinity primary antibodies, and optimization tips. Continue reading for more information! In no time you will be able inform yourself about your experiments. So, how can you best use this marker?
The GFRA2 markers regulate the activity of cells within the immune system. The GFRA2 indicator also includes many other genes. This gene could be used to replace IL33. GFRA2 also expresses in IL33.
The GFRA2 marker is a highly relevant target for the development of high-affinity primary antibodies for glioma. This marker can be found on many cellular structures, including glial cells. High-affinity antibody forms ligand/antibody bonds with a KD of between 10 and 5 mg. This target is also blocked by antibodies.
There are many genes that can be found in basket cells. A few of these include Adamts15, March21, Tfap2b and Tfap2a. These markers are ordered by decreasing specificity. You can use this marker to create an antibody that will specifically recognize both these genes. High-affinity antibodies will be effective in treating glioma.
PMID: 9182803 by Baloh R.H., et al. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.
PMID: 9259272 by Suvanto P., et al. Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha.