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- Table of Contents
1 Citations 6 Q&As
Facts about Growth hormone receptor.
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Human | |
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Gene Name: | GHR |
Uniprot: | P10912 |
Entrez: | 2690 |
Belongs to: |
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type I cytokine receptor family |
GH receptor; GHBP; GHR; growth hormone binding protein; Growth Hormone R; growth hormone receptor; serum binding protein; Somatotropin receptor
Mass (kDA):
71.5 kDA
Human | |
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Location: | 5p13.1-p12 |
Sequence: | 5; NC_000005.10 (42423439..42721878) |
Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver.
Cell membrane; Single-pass type I membrane protein. On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Remains fixed to the cell membrane and is not internalized.; [Growth hormone-binding protein]: Secreted. Complexed to a substantial fraction of circulating GH.
If you're interested in knowing more about antibodies, then you may find this article useful. We will discuss Anti-Growth Hormone Marker and Anti-Myelin Basic Protein/MBP Antibody. The GHR is a growth hormone which helps our bodies fight off diseases. This hormone has numerous uses and benefits. But you might be wondering what is the ideal use of these antibodies?
Boster Bio's Anti-Growth Hormone Monoclonal Antibody (GH) reacts with Human Gh2. To use this antibody, you can purchase a blocking peptide. Boster Bio validates its antibodies using IHC and WB. There is no need to worry about the quality of this antibody since it is safe and has been proved effective.
A number of researchers have reported findings using rat GH3 cell lines and mouse AtT20 cells as models to detect pituitary antigens. The pituitary produces GH and adrenocorticotrophins, which are hormones responsible for producing various other chemicals, such as testosterone. Antigens have been linked to pituitary disorders such as hypopituitarism.
Boster Bio's product line research will confirm their efficacy by detaching pituitary antibody. The findings are based on research published in Boster Bio, a peer-reviewed scientific journal. Eatrides J, the researcher and author of this study, supports the findings.
Researchers from a variety of disciplines can submit their research for various species and applications in the Boster Bio product. Researchers will receive product credits for their work, which is applicable to all scientists around the world. The results are reported with confidence by Boster scientists. They are responsible for ensuring the products they develop benefit patients suffering from various ailments, such as hypopituitarism, Cushing's disease and intracranial germinoma that is steroid-responsive.
Researchers also studied a case of familial isolated hormone deficiency type 2. Researchers also found a unique mutation in the GH-1 genes, known as IVS3+2T>C. This mutation is responsible for the production gonadotropin, pro more auclapll lclaTSH.
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PMID: 2825030 by Leung D.W., et al. Growth hormone receptor and serum binding protein: purification, cloning and expression. PMID: 2813379 by Godowski P.J., et al. Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron- type dwarfism.AOter andibodies
References
*More publications can be found for each product on its corresponding product page