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- Table of Contents
GRM2 Antibodies
AND GRM2 ELISA kits, GRM2 Proteins
Many biological assays use antibodies to detect GRM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRM2 antibodies...
Designing a Western blot for GRM2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GRM2 Western Blot GuideDesigning an IHC experiment for GRM2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the GRM2 IHC GuideGRM2 Infographic by Boster Bio
All GRM2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A06123-1
100 μg/vial
Cat # A06123-1
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M06123
100 μl
Cat # M06123
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1365
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1365
1 kit, containing one 96-well plate and all necessary reagents
Human
$960
Cat # LS002912
20 µg, 100 µg
Cat # LS002912
20 µg, 100 µg
GRM2 Overview
Facts about Metabotropic glutamate receptor 2.
Metabotropic glutamate receptor 2 (GRM2)
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Gene Information
| Human | |
|---|---|
| Gene Name: | GRM2 |
| Uniprot: | Q14416 |
| Entrez: | 2912 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 3 family |
Alternative Names
GLUR2; glutamate metabotropic receptor 2; glutamate receptor, metabotropic 2; GPRC1Bmetabotropic glutamate receptor 2; mGlu2; mGluR2; mGluR2/3; MGLUR2glutamate receptor homolog
Molecular Weight
Mass (kDA):
95.568 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.2 |
| Sequence: | 3; NC_000003.12 (51707068..51718616) |
Tissue Specificity
Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite.
Diseases
- Schizophrenia
- Mental Disorders
- Depressive Disorder
- Psychotic Disorders
- Impaired Cognition
- Neoplasm Metastasis
- Malnutrition
- Mood Disorders
- Malignant Tumor Of Colon
- Hypokinesia
- Carcinoma
- Memory Disorders
Interacting Proteins
- NAALADL2
Pathways
- Pathogenesis
- Cognition
- Localization
- Neuroprotection
- Translation
- Response To Amphetamine
- Histone Acetylation
PTMs
Research Areas
- Apoptosis
- Cancer
- GPCR
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
- Tumor Suppressors
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRM2
bosterbio.com/bosterbio-gene-info-cards/GRM2
References
PMID: 7620613 by Flor P.J., et al. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2.
PMID: 18297054 by Gonzalez-Maeso J., et al. Identification of a serotonin/glutamate receptor complex implicated in psychosis.