Gasdermin-E Antibodies

AND GSDME ELISA kits, Gasdermin-E Proteins

Many biological assays use antibodies to detect Gasdermin-E, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gasdermin-E in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gasdermin-E antibodies...

We validate the specificity of these antibodies to Gasdermin-E by testing them on tissues known to express GSDME positively and negatively. Browse below to find the GSDME antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Gasdermin-E? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the GSDME Western Blot Guide

GSDME Infographic by Boster Bio

All GSDME Products

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Specificity

Applications

Price

Anti-GSDME Antibody Picoband®

Western blot analysis of DFNA5/GSDME using anti-DFNA5/GSDME antibody (A32407-2)

IHC analysis of DFNA5/GSDME using anti-DFNA5/GSDME antibody (A32407-2)

Western blot analysis of GSDME using anti-GSDME antibody (A32407-2)

Human

ELISA, Flow Cytometry, IP, IF, ICC, WB

$370
Cat # A32407-2
100 μg/vial

Anti-DFNA5/GSDME Rabbit Monoclonal Antibody

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-DFNA5/GSDME antibody

Human, Mouse, Rat

ELISA, IP, IF, WB

$146
Cat # M05604-1
20μL, 40μL, 100μL, 200μL

GSDME (NM_004403) Human Over-expression Lysate

GSDME Human Over-expression Lysates NM_001127453

Human

$628
Cat # LS001687
20 µg, 100 µg

Anti-Zebrafish GSDMEA Antibody

IHC analysis of GSDMEA using anti-GSDMEA antibody (AZE7F9U2)

Zebrafish

IHC

$470
Cat # AZE7F9U2
100 μg/vial

GSDME Overview

Facts about Gasdermin-E.

GSDME 3D structure. Source: alphafold

Gasdermin-E (GSDME)

Plays a role in the TP53-regulated cellular response to DNA damage likely by cooperating with TP53 (PubMed:16897187, PubMed:18223688). .

Gene Information

Human
Gene Name:	GSDME
Uniprot:	O60443
Entrez:	1687

Family

Belongs to:

gasdermin family

Alternative Names

Gasdermin-E

Molecular Weight

Mass (kDA):
54.555 kDA

Genomic Context


Human

Location:	7p15.3
Sequence:	7; NC_000007.14 (24698355..24762235, complement)

Tissue Specificity

Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta.

Subcellular Localizations

[Gasdermin-E, N-terminal]: Cell membrane.; [Gasdermin-E]: Cytoplasm, cytosol.

Diseases

Deafness, autosomal dominant, 5 (DFNA5)

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GSDME

References

PMID: 9771715 by Van Laer L., et al. Nonsyndromic hearing impairment is associated with a mutation in DFNA5.

PMID: 9523727 by Thompson D.A., et al. Characterization of a gene that is inversely correlated with estrogen receptor expression (ICERE-1) in breast carcinomas.