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- Table of Contents
Growth hormone receptor Antibodies
AND GHR ELISA kits, Growth hormone receptor Proteins
Many biological assays use antibodies to detect Growth hormone receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Growth hormone receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Growth hormone receptor antibodies...
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GHR Infographic by Boster Bio
All GHR Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1467
96 wells/kit, with removable strips.
Cat # EK1467
96 wells/kit, with removable strips.
Anti-Growth hormone receptor/GHR Antibody Picoband®
1 Citations 6 Q&As
Mouse, Rat
WB
$370
Cat # PA1726
100 μg/vial
Cat # PA1726
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00698
100 μg/vial
Cat # A00698
100 μg/vial
Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00698-1
100 μg/vial
Cat # A00698-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, ICC, WB
$405
Cat # A00698-2
100ul
Cat # A00698-2
100ul
SDS-PAGE, Bioactivity
$250
Cat # PROTP10912
Starting from 10ug
Cat # PROTP10912
Starting from 10ug
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M00698-1
100 μl/vial
Cat # M00698-1
100 μl/vial
GHR Overview
Facts about Growth hormone receptor.
Growth hormone receptor (GHR)
Receptor for pituitary hormone growth hormone involved in regulating postnatal body growth. On ligand binding, couples into the JAK2/STAT5 pathway (By similarity).
. .
Gene Information
| Human | |
|---|---|
| Gene Name: | GHR |
| Uniprot: | P10912 |
| Entrez: | 2690 |
Family
| Belongs to: |
|---|
| type I cytokine receptor family |
Alternative Names
GH receptor; GHBP; GHR; growth hormone binding protein; Growth Hormone R; growth hormone receptor; serum binding protein; Somatotropin receptor
Molecular Weight
Mass (kDA):
71.5 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5p13.1-p12 |
| Sequence: | 5; NC_000005.10 (42423439..42721878) |
Tissue Specificity
Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Remains fixed to the cell membrane and is not internalized.; [Growth hormone-binding protein]: Secreted. Complexed to a substantial fraction of circulating GH.
Diseases
- Dwarfism
- Growth Disorders
- Pituitary Diseases
- Laron Syndrome
- Janiceps
- Malignant Neoplasms
- Neoplasms
- Shwachman Syndrome
- Somatotropin Deficiency
- Diabetes Mellitus
- Obesity
- Acromegaly
Interacting Proteins
- DUSP7
- GH1
- NCK1
- Ncoa6
- PTPN1
- PTPN2
- PTPN3
- PTPN9
- PTPRB
- PTPRH
Pathways
- Secretion
- Localization
- Cell Proliferation
- Proteolysis
- Lactation
- Endocytosis
- Regulation Of Growth
- Reverse Transcription
- Transport
- Translation
- Pathogenesis
- Aging
- Ubiquitin-dependent Endocytosis
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Dephosphorylation
- Biotinylation
- Glycosylation
- Iodination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GHR
bosterbio.com/bosterbio-gene-info-cards/GHR
References
PMID: 2825030 by Leung D.W., et al. Growth hormone receptor and serum binding protein: purification, cloning and expression.
PMID: 2813379 by Godowski P.J., et al. Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron- type dwarfism.
1 Publications of Boster Growth hormone receptor Antibodies & ELISA Kits
- PubMed ID: 10.1126/sciadv.abg6005, Mesenchymal growth hormone receptor deficiency leads to failure of alveolar prog...
*More publications can be found for each product on its corresponding product page