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- Table of Contents
Facts about HCLS1-associated protein X-1.
Involved from the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters like ABCB11.
Human | |
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Gene Name: | HAX1 |
Uniprot: | O00165 |
Entrez: | 10456 |
Belongs to: |
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HAX1 family |
FLJ17042; FLJ93803; HAX1; HAX-1; HCLS1 (and PKD2) associated protein; HCLS1 associated protein X-1; HCLS1-associated protein X-1; HCLSBP1; HS1 binding protein; HS1-associating protein X-1; HS1-binding protein 1; HS1BP1; HS1BP1FLJ18492; HSP1BP-1; SCN3
Mass (kDA):
31.621 kDA
Human | |
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Location: | 1q21.3 |
Sequence: | 1; NC_000001.11 (154272629..154275875) |
Ubiquitous. Up-regulated in oral cancers.
Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Cytoplasm, cell cortex. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum. Cytoplasm, P-body.; [Isoform 1]: Cytoplasm. Nucleus. Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro).; [Isoform 3]: Cytoplasm. Nucleus. Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro).; [Isoform 4]: Cytoplasm. Nucleus. Shuttles between nucleus and cytopl
PMID: 9058808 by Suzuki Y., et al. HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.
PMID: 18472110 by Lees D.M., et al. Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues.