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- Table of Contents
HAX1 Antibodies
AND HAX1 ELISA kits, HAX1 Proteins
Many biological assays use antibodies to detect HAX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HAX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HAX1 antibodies...
Designing an IHC experiment for HAX1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the HAX1 IHC GuideHAX1 Infographic by Boster Bio
All HAX1 Products
Product
Figures
Specificity
Applications
Price
HAX1 Overview
Facts about HCLS1-associated protein X-1.
HCLS1-associated protein X-1 (HAX1)
Recruits that the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484).
Involved from the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters like ABCB11.
Gene Information
| Human | |
|---|---|
| Gene Name: | HAX1 |
| Uniprot: | O00165 |
| Entrez: | 10456 |
Family
| Belongs to: |
|---|
| HAX1 family |
Alternative Names
FLJ17042; FLJ93803; HAX1; HAX-1; HCLS1 (and PKD2) associated protein; HCLS1 associated protein X-1; HCLS1-associated protein X-1; HCLSBP1; HS1 binding protein; HS1-associating protein X-1; HS1-binding protein 1; HS1BP1; HS1BP1FLJ18492; HSP1BP-1; SCN3
Molecular Weight
Mass (kDA):
31.621 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (154272629..154275875) |
Tissue Specificity
Ubiquitous. Up-regulated in oral cancers.
Subcellular Localizations
Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Cytoplasm, cell cortex. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum. Cytoplasm, P-body.; [Isoform 1]: Cytoplasm. Nucleus. Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro).; [Isoform 3]: Cytoplasm. Nucleus. Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro).; [Isoform 4]: Cytoplasm. Nucleus. Shuttles between nucleus and cytopl
Diseases
- Severe Congenital Neutropenia
- Immunologic Deficiency Syndromes
- Infective Disorder
- Leukemia
- Malignant Neoplasms
- Growth Arrest
- Bacterial Infections
- Cell Transformation, Neoplastic
- Neoplasms
- Primary Immune Deficiency Disorder
- Dysmyelopoietic Syndromes
- Developmental Disabilities
- Myeloid Leukemia
Interacting Proteins
- ESR1
- GRB7
- IL1A
- PELO
- SAV1
- TPCN1
- TPCN2
Pathways
- Localization
- Cell Death
- Transport
- Cell Migration
- Cell Proliferation
- Pathogenesis
- Programmed Cell Death
- Translation
- Cell Motility
- Induction Of Apoptosis
- Cell Growth
- Nuclear Export
- Cell Cycle
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HAX1
bosterbio.com/bosterbio-gene-info-cards/HAX1
References
PMID: 9058808 by Suzuki Y., et al. HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.
PMID: 18472110 by Lees D.M., et al. Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues.