HMGCS1 Antibodies

AND HMGCS1 ELISA kits, HMGCS1 Proteins

Many biological assays use antibodies to detect HMGCS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HMGCS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HMGCS1 antibodies...

We validate the specificity of these antibodies to HMGCS1 by testing them on tissues known to express HMGCS1 positively and negatively. Browse below to find the HMGCS1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for HMGCS1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the HMGCS1 Western Blot Guide

HMGCS1 Infographic by Boster Bio

All HMGCS1 Products

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Applications

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Anti-HMGCS1 Antibody Picoband®

Western blot analysis of HMGCS1 using anti-HMGCS1 antibody (A05313-2)

IHC analysis of HMGCS1 using anti-HMGCS1 antibody (A05313-2)

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A05313-2
100 μg/vial

Anti-HMGCS1 Antibody

Western blot analysis of HMGCS1 expression in Hela (A), Jurkat (B), mouse liver (C), rat spinal cord (D) whole cell lysates

Immunofluorescent analysis of HMGCS1 staining in HeLa cells

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A05313
100ul

Anti-HMGCS1 Antibody (Center)

HMGCS1 Antibody (Center) western blot analysis in U87-MG cell line,mouse liver and rat liver lysates (35ug/lane)

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with HMGCS1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining

Flow cytometric analysis of hela cells using HMGCS1 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram)

Human, Mouse

Flow Cytometry, IHC-P, WB

$299
Cat # A05313-1
80 µl

HMGCS1 (NM_001098272) Human Over-expression Lysate

HMGCS1 Human Over-expression Lysates NM_001098272

Human

$960
Cat # LS003157
20 µg, 100 µg

HMGCS1 (NM_002130) Human Recombinant Protein

Coomassie blue staining of purified HMGCS1 protein

$1062
Cat # PROTQ01581
20 µg

HMGCS1 Overview

Facts about Hydroxymethylglutaryl-CoA synthase, cytoplasmic.

HMGCS1 3D structure. Source: alphafold

Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. .

Gene Information

Human
Gene Name:	HMGCS1
Uniprot:	Q01581
Entrez:	3157

Family

Belongs to:

thiolase-like superfamily

Alternative Names

3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); EC 2.3.3.10; HMG-CoA synthase; HMGCS; hydroxymethylglutaryl-CoA synthase, cytoplasmic; MGC90332

Molecular Weight

Mass (kDA):
57.294 kDA

Genomic Context


Human

Location:	5p12
Sequence:	5; NC_000005.10 (43287470..43313477, complement)

Subcellular Localizations

Cytoplasm.

Diseases

Glioma
Malignant Neoplasms
Liver Carcinoma
Schizophrenia
Leukemia
Liver Neoplasms
Inflammation
Hepatitis, Chronic
Malignant Neoplasm Of Breast
Neurodegenerative Disorders
Liver Damage
Hypoxia
Leydig Cell Hyperplasia

Malignant Neoplasm Of Liver
Carcinogenesis
Fibrosis
Refractory Anemia With Ringed Sideroblasts
Abnormal Degeneration
Altitude Sickness
Neuroblastoma

Pathways

Transport
Myelination
Short-chain Fatty Acid Transport
Lactation
Parturition
Response To Hypoxia
Keratinocyte Differentiation
Localization
Spermatogenesis
Senescence
Methylation
Regeneration
Neuroprotection

Fatty Acid Transport
Tissue Regeneration
Cell Cycle
Cell Growth
Luteinization
Pathogenesis
Cholesterol Homeostasis

PTMs

Deacetylation

Oxidation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMGCS1

References

PMID: 1358203 by Russ A.P., et al. Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

PMID: 7913309 by Rokosz L.L., et al. Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild- type and Cys129 mutant enzymes.