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- Table of Contents
HSD3B1 Antibodies
AND HSD3B1 ELISA kits, HSD3B1 Proteins
Many biological assays use antibodies to detect HSD3B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSD3B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSD3B1 antibodies...
Designing a Western blot for HSD3B1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HSD3B1 Western Blot GuideHSD3B1 Infographic by Boster Bio
All HSD3B1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # M02856
100 μg/vial
Cat # M02856
100 μg/vial
Anti-HSD3B1 Antibody Picoband®
3 Citations
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02856-2
100 μg/vial
Cat # A02856-2
100 μg/vial
HSD3B1 Overview
Facts about 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1.
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3- oxo-Delta(4)-steroids, an important step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone into 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4- androstenedione, and androstenediol to testosterone.
Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo- 5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR.
Gene Information
| Human | |
|---|---|
| Gene Name: | HSD3B1 |
| Uniprot: | P14060 |
| Entrez: | 3283 |
Family
| Belongs to: |
|---|
| 3-beta-HSD family |
Alternative Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3BETAHSD; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3BH; delta-5-3-ketosteroid isomerase; EC 1.1.1; HSD3B; HSDB3; HSDB3A; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1; I; progesterone reductase; SDR11E1; short chain dehydrogenase/reductase family 11E, member 1,3-beta-hydroxy-5-ene steroid dehydrogenase; steroid Delta-isomerase; Trop
Molecular Weight
Mass (kDA):
42.252 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p12 |
| Sequence: | 1; NC_000001.11 (119507203..119515058) |
Tissue Specificity
Placenta and skin (PubMed:1401999). Predominantly expressed in mammary gland tissue.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Prostate
- Hypertensive Disease
- Prostatic Neoplasms
- Hyperplasia
- Virilism
- Congenital Adrenal Hyperplasia
- Neoplasms
- Adrenal Hyperplasia
- Cholangiocarcinoma
- Essential Hypertension
- Disorders Of Sex Development
Pathways
- Secretion
- Cell Proliferation
- Luteinization
- Pathogenesis
- Localization
- Sex Differentiation
- Transport
- Translation
- Progesterone Secretion
- Spermatogenesis
- Cell Differentiation
- Dna Methylation
PTMs
- Cleavage
- Oxidation
Research Areas
- Cancer
- Lipid and Metabolism
- Prostate Cancer
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSD3B1
bosterbio.com/bosterbio-gene-info-cards/HSD3B1
References
PMID: 2779585 by Luu-The V., et al. Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase.
PMID: 2139411 by Lorence M.C., et al. Human 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids.
1 Publications of Boster HSD3B1 Antibodies & ELISA Kits
- PubMed ID: 10.1111/and.12581, 4‐Methylcatechol inhibits cell growth and testosterone production in TM3 Leydi...
*More publications can be found for each product on its corresponding product page