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Facts about 60 kDa heat shock protein, mitochondrial.
The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which serve as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and institution with 2 heptameric rings of the co-chaperonin Hsp10.
Human | |
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Gene Name: | HSPD1 |
Uniprot: | P10809 |
Entrez: | 3329 |
Belongs to: |
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chaperonin (HSP60) family |
60 kDa chaperonin; Chaperonin 60; cpn60; GROEL; heat shock 60kD protein 1 (chaperonin); heat shock 60kDa protein 1 (chaperonin); Heat shock protein 60; heat shock protein 65; HLD4; HSP60; HSP-60; HSP60SPG13; HSP65; HSPD1; HuCHA60; Mitochondrial matrix protein P1,60 kDa heat shock protein, mitochondrial; P60 lymphocyte protein; short heat shock protein 60 Hsp60s1; spastic paraplegia 13 (autosomal dominant); SPG13
Mass (kDA):
61.055 kDA
Human | |
---|---|
Location: | 2q33.1 |
Sequence: | 2; NC_000002.12 (197486584..197500274, complement) |
Mitochondrion matrix.
If you are looking for the best HSPD1 ELISA kit, you have come to the right place. Here you will learn more about the HSPD1 marker. HSPD1 is also known as DNAJA1, HSPB1, or HSPB1. In this article, we will discuss the best uses of these markers for a wide range of samples. We will also discuss the benefits of these ELISA kits and their various uses.
The Boster Bio Anti-HSPD1 antibody Picoband is a highly specific, 6G2-derived monoclonal antibody for the detection of HSPD1. It has been validated for multiple applications and is made of E. coli-derived proteins. The product comes with a 4-mg trehalose dilution and is tested for multiple applications. It is available in multiple formats and contains high-quality lysis buffers.
If you're looking for a new HSPE1 marker for a PCR assay, you've come to the right place. Boster Bio ELISA kits provide comprehensive detection of hormones, small molecules, oxidative stress, DNA damage, and inflammatory cytokines. These kits contain sufficient reagents to run 96 tests and are validated for a wide range of samples. You can use Boster Bio Anti-HSPE1 antibody in ELISA, Flow Cytometry, and Immunofluorescence assays.
The antibodies in Boster's Picokine(tm) platform are highly sensitive and have high specificity. These antibodies have been validated against a variety of samples, including cancer, neurological disorders, and developmental biology. They are also backed by technical support. Best Uses Of The HSPE1 marker and Boster Bio ELISA kits can be purchased from tebu-bio.
J2 inhibits HSPB1 oligomerization and contributes to attenuation of inflammatory airway diseases, such as asthma and COPD. J2 also enhances Ym1 expression in M2 macrophages via IL-4/STAT6 signaling. This protein also inhibits IL-8 production by airway epithelial cells. Therefore, J2 is an important candidate for therapeutic application.
HSPB1 is known to regulate gene expression by modifying histones. The UCSC genome browser revealed that HSPB1 is present in the MED29 promoter region. JASPAR database analysis predicted that HSPB1 binds to LYS27Ac and H3K4me1. In addition, ChIP-qPCR demonstrated reduced levels of H3K4me1 and H3K27ac in MED29 cells. The result was a highly specific response to si-HSPB1.
The HSPB1 gene is essential for the development of many types of cancer. Overexpression of this gene is associated with poor clinical outcomes in several human cancers. Additionally, HSPB1 modulates cancer cell migration and mediates the epithelial-mesenchymal transition. Therefore, HSPB1 inhibitory drugs are viewed as a potential therapeutic for cancer growth and fibrosis, a condition caused by persistent myofibroblast activation.
The expression of HSPB1 is increased in response to various stresses and conditions. It is regulated by various pathways and maintains cancer stem cells. Additionally, HSPs can limit the response to cancer therapies. Inhibitors of HSPs inhibit the activity of HSPB1 in cancer cells, thus limiting their response to these treatments. They also act to modulate cellular proteostasis. Therefore, AS-tDR-007333 inhibits HSPB1 expression in human tumor cells.
A Boster Bio is an ELISA kit which contains the HSPD1 marker. This marker is used for the investigation and manipulation of genetic material. The Boster Bio platform offers a wealth of technical resources such as blogs, disease information, and web-based digital tools. Boster also offers high-quality lysis buffers which are essential for good results. HSPD1 is one of the most abundant proteins in the body and is found in all tissues and cells.
The company produces ELISA kits for detection of HSPD1 and other cellular proteins. Its antibodies are picogram-level sensitive and are validated on multiple platforms. The company also offers validation images and procedures for all its products. The Boster Bio team provides excellent technical support for the antibody kits and services. These antibodies can be purchased through tebu-bio, an online store where Boster sells its products.
The HSSPA8 marker is a highly useful genetic locus. It has several applications in the scientific community. The ability to manipulate genetic material with DNA manipulation allows researchers to study a variety of diseases and conditions. The Boster Bio technology is designed to facilitate the use of a range of different genetic markers in a wide variety of experiments. The company offers an extensive set of technical resources and tools, including blogs, disease information, web-based digital tools, and high-quality lysis buffers. These reagents ensure good results by reducing cross-linking intensity and ensuring a high level of purity.
Boster Bio is an antibody manufacturer with a broad portfolio of antibodies for research. Boster Biologicals' research antibodies are optimized for immunohistology (IHC), western blotting (WB), and flow cytometry. They are validated quantitatively against a panel of 250 tissue samples and untransfected cell lines. Their proprietary methods produce high affinity, specificity, and sensitivity.
The HSP60 peptide is found in all tissues, including blood cells, tissues, and brain. HSP60 downregulates adaptive immune responses and upregulates Treg cells via TLR2 signaling. In addition to its role in immune regulation, HSP60 has other roles in the body. Here are some of its best uses:
HSPD1/HSPE1 bidirectional promoter contains a CHOP-10-C/EBPb binding element that is critical for activation of UPRmt-responsive genes. Enhanced OTC levels increased the abundance of this element. UPRmt-induced gene expression requires the expression of transcription factors. These factors activate the gene expression of mitochondrial chaperones, chaperonins, and proteases.
PMID: 2568584 by Jindal S., et al. Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.
PMID: 1980192 by Venner T.J., et al. Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families.
*More publications can be found for each product on its corresponding product page