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- Table of Contents
HSPH1 Antibodies
AND HSPH1 ELISA kits, HSPH1 Proteins
Many biological assays use antibodies to detect HSPH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSPH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSPH1 antibodies...
Designing a Western blot for HSPH1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HSPH1 Western Blot GuideHSPH1 Infographic by Boster Bio
All HSPH1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M04372
100 μg/vial
Cat # M04372
100 μg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M04168-1
100 μg/vial
Cat # M04168-1
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, ICC, WB
$370
Cat # A04168
100 μg/vial
Cat # A04168
100 μg/vial
Human
IF, IHC, WB
$370
Cat # M04393-2
100 μg/vial
Cat # M04393-2
100 μg/vial
Human
Flow Cytometry, IHC, WB
$370
Cat # M04201
100 μg/vial
Cat # M04201
100 μg/vial
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M04168
100 μl
Cat # M04168
100 μl
HSPH1 Overview
Facts about Heat shock protein 105 kDa.
Heat shock protein 105 kDa (HSPH1)
Acts as a nucleotide-exchange variable (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly.
Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | HSPH1 |
| Uniprot: | Q92598 |
| Entrez: | 10808 |
Family
| Belongs to: |
|---|
| heat shock protein 70 family |
Alternative Names
Antigen NY-CO-25; heat shock 105kD beta; heat shock 105kDa protein 1; heat shock 105kDa/110kDa protein 1; Heat shock 110 kDa protein; heat shock protein 105 kDa; HSP105a; HSP105B; HSP105heat shock 105kD alpha; HSP110; HSPH1; KIAA0201DKFZp686M05240; NY-CO-25
Molecular Weight
Mass (kDA):
96.865 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q12.3 |
| Sequence: | 13; NC_000013.11 (31134973..31162388, complement) |
Tissue Specificity
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Carcinoma
- Melanoma
- Lymphoma
- Adenocarcinoma
- Skin Neoplasms
- Neurodegenerative Disorders
- Malignant Squamous Cell Neoplasm
- Swine Diseases
- Pancreatic Adenocarcinoma
Interacting Proteins
- Phlda1
Pathways
- Cell Death
- Localization
- Cell Cycle
- Translation
- Transport
- Fertilization
- Zinc Ion Homeostasis
- Oocyte Maturation
- Response To Heat
- Sperm-egg Recognition
- Ion Homeostasis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSPH1
bosterbio.com/bosterbio-gene-info-cards/HSPH1
References
PMID: 9931472 by Ishihara K., et al. Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105.
PMID: 9610721 by Scanlan M.J., et al. Characterization of human colon cancer antigens recognized by autologous antibodies.