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- Table of Contents
IFITM1 Antibodies
AND IFITM1 ELISA kits, IFITM1 Proteins
Many biological assays use antibodies to detect IFITM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IFITM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IFITM1 antibodies...
Designing a Western blot for IFITM1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IFITM1 Western Blot GuideIFITM1 Infographic by Boster Bio
All IFITM1 Products
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Specificity
Applications
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IFITM1 Overview
Facts about Interferon-induced transmembrane protein 1.
Interferon-induced transmembrane protein 1 (IFITM1)
IFN-induced antiviral protein that inhibits the entry of viruses into the host cell cytoplasm, allowing endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV).
Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | IFITM1 |
| Uniprot: | P13164 |
| Entrez: | 8519 |
Family
| Belongs to: |
|---|
| CD225/Dispanin family |
Alternative Names
CD225 antigen; CD225; CD225Leu-13 antigen; IFI17; IFI17LEU13,9-27; IFITM1; interferon induced transmembrane protein 1 (9-27); Interferon-induced protein 17; interferon-induced transmembrane protein 1; Interferon-inducible protein 9-27; Leu-13
Molecular Weight
Mass (kDA):
13.964 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.5 |
| Sequence: | 11; NC_000011.10 (314040..315272) |
Tissue Specificity
Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.
Subcellular Localizations
Cell membrane; Single-pass membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Tissue Adhesions
- Virus Diseases
- Malignant Squamous Cell Neoplasm
- Adenocarcinoma
- Hepatitis
- Colorectal Cancer
- Cell Invasion
- Neoplasm Metastasis
- Carcinogenesis
- Influenza
Pathways
- Pathogenesis
- Cell Adhesion
- Immune Response
- Cell Cycle
- Localization
- Cell Proliferation
- Germ Cell Development
- Cell Development
- Cell Differentiation
- Secretion
- Transport
- Virulence
- Reverse Transcription
PTMs
- Phosphorylation
- Demethylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFITM1
bosterbio.com/bosterbio-gene-info-cards/IFITM1
References
PMID: 2492664 by Reid L.E., et al. A single DNA response element can confer inducibility by both alpha- and gamma-interferons.
PMID: 7559564 by Deblandre G.A., et al. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth.
5 Publications of Boster IFITM1 Antibodies & ELISA Kits
- PubMed ID: 10.1158/1078-0432.CCR-07-4761, IFN-Induced Transmembrane Protein 1 Promotes Invasion at Early Stage of Head and...
- PubMed ID: 10.1038/sj.onc.1209807, IFITM1 plays an essential role in the antiproliferative action of interferon- γ
- PubMed ID: 16847454, Yang G, Xu Y, Chen X, Hu G. Oncogene. 2007 Jan 25;26(4):594-603. Epub 2006 Jul 1...
- PubMed ID: 19499152, Xu Y, Yang G, Hu G. Acta Biochim Biophys Sin (Shanghai). 2009 Jun;41(6):488-94. ...
- PubMed ID: 20428811, Ma Y, Zhang G, Fu X, Xia O, Zhan C, Li L, Wang Z, Wu B. Oncol Rep. 2010 Jun;23(6...
*More publications can be found for each product on its corresponding product page