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1 Citations 8 Q&As
Facts about Interferon lambda-2.
Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its own receptor IFNLR1.
Human | |
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Gene Name: | IFNL2 |
Uniprot: | Q8IZJ0 |
Entrez: | 282616 |
Belongs to: |
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lambda interferon family |
interleukin-28A; IFN-lambda 2; IL28A; IL-28A; interferon, lambda 2
Mass (kDA):
22.288 kDA
Human | |
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Location: | 19q13.2 |
Sequence: | 19; NC_000019.10 (39268396..39270188) |
Secreted.
If you are looking for a high-affinity primary antibody to the IL-28 protein, you have probably considered buying Boster Bio's Anti-IL-28 IFNL2 Marker. Before you make your purchase, it is important to understand the marker and how to use it. Fortunately, the company behind Boster has a history of developing high-quality primary antibodies that have a long shelf life.
Boster Bio Anti-IL-28 is an ifnl2 marker that uses a rabbit polyclonal antibodies as a model system. The immune system releases the antigen. It plays a critical role for host defense and epithelial cells. Monoclonal antibody are non-hazardous and come without BSA, or other chemicals. Boster Bio checks their antibodies against known positive or negative samples to ensure that they are reliable and accurate.
If you're looking for a highly specific antibody that recognizes human and mouse IFNL2 protein, look no further than the Boster Bio product line. Boster Bio's ELISA Kits, primary antibodies, & secondary antibodies are designed for use in combination to detect protein within a variety o biological systems. The company offers a wide range of products that cover a variety research areas such as neuroscience, immunology, chemistry, and more. Boster's Quality Guarantee ensures that each antibody will perform as promised.
Secondary antibodies are not a suitable complement for the primary antibody because they do not recognize the same epitope as the primary antibody. Dual antibody detection requires an additional step of incubation, as they are bound to the same IFNL2 marker. This method is extremely sensitive, but it requires more optimization to minimize cross reaction. This is the preferred option, but it requires more work and expense.
High-affinity primary antibody use the IFN-2 marker to recognize an epitope within fixed tissue. These antibodies can wash out non-specific bound materials and are a useful tool to measure specific analytes within a crude preparation. High affinity antibodies can prove problematic because they can be difficult to separate the antigen from them. The removal of antibodies from affinity columns may require more harsh methods that can damage the antigen.
Boster’s high-affinity primary antibodies use the IFNL2 marker. This marker is compatible with a wide array of applications. It can be used to identify many cell types and is especially useful for analysing tumor cells. IFNL2 is a common marker used for tumor antigens and immunohistochemistry, which uses IFNL2 to detect cancer cells.
A study to identify the specific function of IFNs in host defense is needed to understand their role in different immune functions. The effects of IFNs in host defense should be studied on various tissues and cells, as well their role in adaptive and innate immunity. These factors will require further research in the near future. These are possible uses of the IFNL2 marker gene. These might be helpful in developing effective treatments for infectious disorders.
Steven Boster's story can be traced back in the late '90s when he invented his first product. The company grew to become one the most important catalog antibody companies in China. Boster was also well-known for his ability to develop hundreds of primary antibodies. Steven Boster became China's largest catalog antigen company in the late 90s. PicoKine(tm), Boster’s proprietary ELISA platform, was also invented by the inventor. Using his own trade secrets, he has been able to deliver high-sensitivity ELISA kits with unprecedented accuracy and reproducibility.
Born on June 6, 1920, Don "Steve" Boster passed away in Madison, WI. He was a long-standing sales manager for retail and was a member Concordia Hall in Staunton. In addition to his two daughters, Crystal Boster and Natosha Peck, he is survived by his four siblings - Jack Boster, Sandra Blanton, and Lisa Milton. Boster had numerous nieces/nephews.
PMID: 12469119 by Sheppard P., et al. IL-28, IL-29 and their class II cytokine receptor IL-28R.
PMID: 16146571 by Zhu H., et al. Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication.
*More publications can be found for each product on its corresponding product page