Insulin-like growth factor 1 receptor (IGF1R)

Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity.

The activated IGF1R is involved in cell growth and survival management. IGF1R is crucial for tumor survival and transformation of malignant cell.