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- Table of Contents
IL23A Antibodies
AND IL23A ELISA kits, IL23A Proteins
Many biological assays use antibodies to detect IL23A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL23A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL23A antibodies...
Designing a Western blot for IL23A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IL23A Western Blot GuideDesigning an IHC experiment for IL23A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the IL23A IHC GuideIL23A Infographic by Boster Bio
All IL23A Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01097-1
100 μg
Cat # M01097-1
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01097-2
100 μg
Cat # M01097-2
100 μg
Human, Rabbit
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01097-6
100 μg
Cat # M01097-6
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01097-5
100 μg
Cat # M01097-5
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01097-4
100 μg
Cat # M01097-4
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01097-3
100 μg
Cat # M01097-3
100 μg
Human
Cell Culture
$77
Cat # PROTQ9NPF7-3
5ug,20ug,100ug
Cat # PROTQ9NPF7-3
5ug,20ug,100ug
IL23A Overview
Facts about Interleukin-23 subunit alpha.
Interleukin-23 subunit alpha (IL23A)
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.
IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory as opposed to naive T- cells and boosts production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may cause autoimmune inflammatory diseases and may be important for tumorigenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | IL23A |
| Uniprot: | Q9NPF7 |
| Entrez: | 51561 |
Family
| Belongs to: |
|---|
| IL-6 superfamily |
Alternative Names
IL-23 p19/IL-12 p40; IL23; IL-23; IL-23A; IL-23-A; IL-23p19; IL-23p19/IL-12p40; IL23P19P19; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; JKA3 induced upon T-cell activation; MGC79388; SGRF; SGRFIL-23 subunit alpha
Molecular Weight
Mass (kDA):
20.73 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.3 |
| Sequence: | 12; NC_000012.12 (56334159..56340410) |
Tissue Specificity
Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Subcellular Localizations
Secreted. Secreted upon association with IL12B.
Diseases
- Inflammation
- Autoimmune Reaction
- Autoimmune Diseases
- Neoplasms
- Autoimmunity
- Experimental Autoimmune Encephalomyelitis
- Arthritis
- Psoriasis
- Encephalomyelitis
- Infective Disorder
- Tuberculosis
- Multiple Sclerosis
- Salmonella Infections
Interacting Proteins
- IL12B
- PEX19
Pathways
- Immune Response
- Pathogenesis
- Secretion
- Cytokine Production
- Cell Activation
- Interferon-gamma Production
- Inflammatory Response
- Cell Differentiation
- Hypersensitivity
- Reverse Transcription
- Translation
- Granuloma Formation
- Cell Proliferation
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL23A
bosterbio.com/bosterbio-gene-info-cards/IL23A
References
PMID: 11114383 by Oppmann B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
PMID: 12023369 by Parham C., et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL- 12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
12 Publications of Boster IL23A Antibodies & ELISA Kits
- PubMed ID: PMID:27725852, MicroRNA-155 in exosomes secreted from helicobacter pylori infection macrophages...
- PubMed ID: 10.3748/wjg.15.1821, Therapeutic effects of Clostridium butyricum on experimental colitis induced by ...
- PubMed ID: 10.3389/fphar.2020.613160, Bazedoxifene Regulates Th17 Immune Response to Ameliorate Experimental Autoimmun...
- PubMed ID: 10.1177/2058739219832489, Effects of thermal ablation on Treg/Th17 in hepatocellular carcinoma of mice:
- PubMed ID: 10.1097/MEG.0000000000001712, Upregulation of microRNA-219-5p relieves ulcerative colitis through balancing th...
- PubMed ID: 10.1089/jir.2015.0030, Effects of Bacillus subtilis on Epithelial Tight Junctions of Mice with Inflamma...
- PubMed ID: 10.1016/j.prp.2017.08.001, miR-155 targets Est-1 and induces ulcerative colitis via the IL-23/17/6-mediated...
- PubMed ID: 10.1016/j.ijbiomac.2018.12.216, Structure elucidation and bioactivities of a new polysaccharide from Xiaojin Bol...
- PubMed ID: 10.1016/j.fct.2020.111244, Ganoderma atrum polysaccharide ameliorates intestinal mucosal dysfunction associ...
- PubMed ID: 33434535, Li B,Du P,Du Y,Zhao D,Cai Y,Yang Q,Guo Z.Luteolin alleviates inflammation and mo...
- PubMed ID: 27725852, MicroRNA-155 in exosomes secreted from helicobacter pylori infection macrophages...
- PubMed ID: 19370778, Zhang Hq, Ding Tt, Zhao Js, Yang X, Zhang Hx, Zhang Jj, Cui Yl. World J Gastroen...
*More publications can be found for each product on its corresponding product page