This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Interferon regulatory factor 2.
Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth.
Human | |
---|---|
Gene Name: | IRF2 |
Uniprot: | P14316 |
Entrez: | 3660 |
Belongs to: |
---|
IRF family |
DKFZp686F0244; interferon regulatory factor 2; IRF2; IRF-2
Mass (kDA):
39.354 kDA
Human | |
---|---|
Location: | 4q35.1 |
Sequence: | 4; NC_000004.12 (184382741..184474580, complement) |
Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
Nucleus.
This article reviews the Boster Bio: Anti Interferon regulatory factor 2, IRF2 Marker, PicoKine(tm), ELISA kits and high-affinity prima antibody. This article provides the advantages of these products and assists you select the right one for your research. Whatever your research objectives you'll find the Boster product that will satisfy your requirements.
Boster Bio's Anti-InterferoN-Regulatory Factor 2 (IRF2) Marker is a mouse monoclonal antibody that binds to the intracellular domain of this interferon gene. This antibody is tested using IF, ICC and WB. It reacts with Human, Mouse and rat samples. It is useful for the detection of GC and IRF2BP2 in various applications, including research and clinical development.
Interferon-Regulator 2, an anti-oncogene which is involved in gastric cancer. However, its mechanism of action is not clear. To understand the role IRF2 plays in GC, the protein's expression levels in GC tissue and adjacent non-tumor tissues were analyzed. Further studies focusing on the tumor proliferation ability were carried out on mice in the absence of and xenograft studies were performed to examine the biological function of IRF2 in GC patients. Moreover, IRF2BP2 is directly targeted by chromatin immunoprecipiterative sequencing (ChIP-seq).
Interferon-Regulatory Factor 2 (IRF2BP2) is essential for the protective and anti-inflammatory effects of IFN-b cytokines. IRF2BP2-deficient microglia also block the anxiolytic impact of postnatal care, and decrease the expression of anti-inflammatory chemicals in the hypothalamus.
This antibody is a potent, sensitive, and specific IRF2 receptor. Boster Bio's Anti-Interferon regulatory Factor 2 IRF2 Marker is an effective tool to detect IRF2 expression in many cancer cells. The antibody is available in three different formats. They allow you to locate an antibody that is specific to IRF2 and determine the cells it targets.
The IRF2BP2 protein is expressed in many tissues and organs of different organisms. It is associated with both hematopoietic and solid tumors. However, the precise role in the process of tumorigenesis is yet be investigated. It is a factor that influences the expression of several key genes involved in the growth and development of tumors. However further research is required to determine if IRF2BP2BP2 has a role in the treatment of cancer.
The Boster Bio PicoKine(tm) is a 96-well strip microplates have EK1452-CAP Antihuman IDS Standard and a Biotinylated antibody and AR1106-1 sample Diluent. A 20ml wash buffer is also included. The pipettes can be used with 0.5-ml volumes and are recommended for larger sample sizes.
High-affinity antibodies against the IRF2 marker are necessary for IHC tests. Boster Bio's range includes more than 12,000 antibodies that have been validated for IHC, WB, and Flow. The antibodies are validated against 250 tissues. Boster antibodies are validated both quantitatively and qualitatively, in comparison to known amounts of recombinant protein and untransfected cell lines.
The IRF2 marker is a common protein found in human samples. The IRF2 gene is found in all cells of the body, including the brain. Boster Bio can provide high-affinity primary antibodies that recognize the IRF2 mark. These antibodies are tested in IP or IHC and are available as 100-ul liquid versions.
These antibodies, which detect the human IRF2 protein with high affinity, were created by an international team. The researchers who developed the new technology include Abazov, V. M., Abbott, B. and M., who is a Russian researcher. Ahn, S. H. and Ahsan M. are included too.
PMID: 2813069 by Itoh S., et al. Sequence of a cDNA coding for human IRF-2.
PMID: 8106512 by Cha Y., et al. Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region.