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- Table of Contents
IRF9 Antibodies
AND IRF9 ELISA kits, IRF9 Proteins
Many biological assays use antibodies to detect IRF9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IRF9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IRF9 antibodies...
Designing a Western blot for IRF9? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IRF9 Western Blot GuideDesigning an IHC experiment for IRF9? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the IRF9 IHC GuideIRF9 Infographic by Boster Bio
All IRF9 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04485
100 μg/vial
Cat # A04485
100 μg/vial
Human
$628
Cat # LS010379
20 µg, 100 µg
Cat # LS010379
20 µg, 100 µg
$1249
Cat # PROTQ00978
20 µg
Cat # PROTQ00978
20 µg
IRF9 Overview
Facts about Interferon regulatory factor 9.
Interferon regulatory factor 9 (IRF9)
Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2.
IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to trigger the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Gene Information
| Human | |
|---|---|
| Gene Name: | IRF9 |
| Uniprot: | Q00978 |
| Entrez: | 10379 |
Family
| Belongs to: |
|---|
| IRF family |
Alternative Names
IFN-alpha-responsive transcription factor subunit; interferon regulatory factor 9; Interferon-stimulated gene factor 3 gamma; interferon-stimulated transcription factor 3, gamma (48kD); interferon-stimulated transcription factor 3, gamma 48kDa; IRF9; IRF-9; ISGF3 p48 subunit; ISGF3; ISGF3G; ISGF3GISGF-3 gamma; p48; Transcriptional regulator ISGF3 subunit gamma
Molecular Weight
Mass (kDA):
43.696 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q12 |
| Sequence: | 14; NC_000014.9 (24161265..24166565) |
Subcellular Localizations
Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
Diseases
- Virus Diseases
- Neoplasms
- Malignant Neoplasms
- Hepatitis
- Carcinoma
- Janiceps
- Leukemia
- Infective Disorder
- Inflammation
- Liver Carcinoma
- Hepatitis C
- Cell Transformation, Neoplastic
- Innate Immune Response
Interacting Proteins
- IFNAR2
- STAT2
Pathways
- Localization
- Immune Response
- Pathogenesis
- Cell Cycle
- Cell Growth
- Cell Proliferation
- Methylation
- Secretion
- Response To Virus
- Innate Immune Response
- Viral Replication
- Cell Death
- Nuclear Export
PTMs
- Phosphorylation
- Methylation
- Dephosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IRF9
bosterbio.com/bosterbio-gene-info-cards/IRF9
References
PMID: 1630447 by Veals S.A., et al. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA- binding proteins.
PMID: 11846981 by Reich N.C.; Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation.