Junctophilin-1 Antibodies

AND JPH1 ELISA kits, Junctophilin-1 Proteins

Many biological assays use antibodies to detect Junctophilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Junctophilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Junctophilin-1 antibodies...

We validate the specificity of these antibodies to Junctophilin-1 by testing them on tissues known to express JPH1 positively and negatively. Browse below to find the JPH1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Junctophilin-1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the JPH1 IHC Guide

JPH1 Infographic by Boster Bio

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Anti-Junctophilin-1 JPH1 Antibody

Western blot analysis of JPH1 in 293 cell lysate with JPH1 antibody at (A) 1 and (B) 2 μg/mL

Immunohistochemistry of JPH1 in mouse skeletal muscle tissue with JPH1 antibody at 2

Human, Mouse, Rat

ELISA, IHC-P, WB

$481
Cat # A08565
0.1 mg

JPH1 Overview

Facts about Junctophilin-1.

JPH1 3D structure. Source: alphafold

Junctophilin-1 (JPH1)

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which connect the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural base for functional cross-talk between the cell surface and intracellular calcium release channels.

JPH1 contributes to the building of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. .

Gene Information

Human
Gene Name:	JPH1
Uniprot:	Q9HDC5
Entrez:	56704

Family

Belongs to:

junctophilin family

Alternative Names

DKFZp762L0313; JP-1junctophilin type1; JP1junctophilin-1; junctophilin 1; Junctophilin type 1; mitsugumin72

Molecular Weight

Mass (kDA):
71.686 kDA

Genomic Context


Human

Location:	8q21.11
Sequence:	8; NC_000008.11 (74234700..74321540, complement)

Tissue Specificity

Abundantly expressed in skeletal muscle. Very low levels in heart.

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands (By similarity).

Diseases

Hypertrophic Cardiomyopathy
Heart Diseases
Cardiomyopathies
Hypertrophy
Cardiac Arrest

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JPH1

References

PMID: 10891348 by Nishi M., et al. Characterization of human junctophilin subtype genes.