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- Table of Contents
KANK2 Antibodies
AND KANK2 ELISA kits, KANK2 Proteins
Many biological assays use antibodies to detect KANK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KANK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KANK2 antibodies...
Designing an IHC experiment for KANK2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KANK2 IHC GuideKANK2 Infographic by Boster Bio
All KANK2 Products
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Specificity
Applications
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KANK2 Overview
Facts about KN motif and ankyrin repeat domain-containing protein 2.
KN motif and ankyrin repeat domain-containing protein 2 (KANK2)
Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081).
May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; suggested to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500).
Gene Information
| Human | |
|---|---|
| Gene Name: | KANK2 |
| Uniprot: | Q63ZY3 |
| Entrez: | 25959 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ANKRD25; ankyrin repeat domain 25; Ankyrin repeat domain-containing protein 25; DKFZp434N161; FLJ20004; KIAA1518SRC1-interacting protein; kidney ankyrin repeat-containing protein 2; KN motif and ankyrin repeat domain-containing protein 2; KN motif and ankyrin repeat domains 2; Matrix-remodeling-associated protein 3; matrix-remodelling associated 3; MGC119707; MXRA3; SIP; SRC-1 interacting protein; SRC-1-interacting protein
Molecular Weight
Mass (kDA):
91.174 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (11164267..11197545, complement) |
Tissue Specificity
Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).
Subcellular Localizations
Cytoplasm. Mitochondrion.
Diseases
- Neoplasms
- Renal Cell Carcinoma
- Carcinoma
Interacting Proteins
- ABI3
- AES
- AIFM1
- CCDC36
- CEP70
- DYNLL1
- EIF4E
- FHL2
- FOXK2
- GOLGA2
Pathways
- Localization
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KANK2
bosterbio.com/bosterbio-gene-info-cards/KANK2
References
PMID: 17476305 by Zhang Y., et al. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.
PMID: 17996375 by Zhu Y., et al. Kank proteins: a new family of ankyrin-repeat domain-containing proteins.