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- Table of Contents
Facts about Kinesin heavy chain isoform 5A.
The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 that's vital for MAPK8IP3/JIP3 function in axon elongation.
Human | |
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Gene Name: | KIF5A |
Uniprot: | Q12840 |
Entrez: | 3798 |
Belongs to: |
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TRAFAC class myosin-kinesin ATPase superfamily |
D12S1889; KIF5A variant protein; kinesin family member 5A; kinesin heavy chain isoform 5A; Kinesin heavy chain neuron-specific 1; kinesin, heavy chain, neuron-specific; MY050; Neuronal kinesin heavy chain; NKHC1; NKHCspastic paraplegia 10 (autosomal dominant); SPG10
Mass (kDA):
117.378 kDA
Human | |
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Location: | 12q13.3 |
Sequence: | 12; NC_000012.12 (57550039..57586633) |
Distributed throughout the CNS but is highly enriched in subsets of neurons.
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Perikaryon. Concentrated in the cell body of the neurons, particularly in the perinuclear region.
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PMID: 7514426 by Niclas J., et al. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons.
PMID: 20386726 by Splinter D., et al. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.