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- Table of Contents
KAT5 Antibodies
AND KAT5 ELISA kits, KAT5 Proteins
Many biological assays use antibodies to detect KAT5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KAT5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KAT5 antibodies...
Designing an IHC experiment for KAT5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KAT5 IHC GuideKAT5 Infographic by Boster Bio
All KAT5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$540
Cat # EKC2210
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2210
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1567
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1567
1 kit, containing one 96-well plate and all necessary reagents
KAT5 Overview
Facts about Histone acetyltransferase KAT5.
Histone acetyltransferase KAT5 (KAT5)
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.
This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Gene Information
| Human | |
|---|---|
| Gene Name: | KAT5 |
| Uniprot: | Q92993 |
| Entrez: | 10524 |
Family
| Belongs to: |
|---|
| MYST (SAS/MOZ) family |
Alternative Names
cPLA2; ESA1EC 2.3.1.48; Histone acetyltransferase HTATIP; histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 Tat interactive protein, 60kDa; HTATIP1; HTATIPcPLA2 interacting protein; K(lysine) acetyltransferase 5,60 kDa Tat-interactive protein; K-acetyltransferase 5; Lysine acetyltransferase 5; PLIPTIP; Tat interacting protein, 60kDa; Tip60; TIP60cPLA(2)-interacting protein
Molecular Weight
Mass (kDA):
58.582 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.1 |
| Sequence: | 11; NC_000011.10 (65712018..65719604) |
Subcellular Localizations
Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Hiv Infections
- Leukemia
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Alzheimer's Disease
- Cell Transformation, Neoplastic
- Ataxia Telangiectasia
- Neoplasm Metastasis
- Genotoxic Stress
- Thyroid Neoplasm
Pathways
- Dna Repair
- Localization
- Cell Cycle
- Histone Acetylation
- Cell Proliferation
- Chromatin Remodeling
- Cell Growth
- Cell Death
- Methylation
- Pathogenesis
- Dna Replication
- Proteolysis
- Cell Cycle Arrest
PTMs
- Acetylation
- Phosphorylation
- Cleavage
- Deacetylation
- Methylation
Research Areas
- Apoptosis
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KAT5
bosterbio.com/bosterbio-gene-info-cards/KAT5
References
PMID: 8607265 by Kamine J., et al. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator.
PMID: 11416127 by Sheridan A.M., et al. PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production.