Kdm8 Antibodies

AND Kdm8 ELISA kits, Kdm8 Proteins

Many biological assays use antibodies to detect Kdm8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kdm8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kdm8 antibodies...

We validate the specificity of these antibodies to Kdm8 by testing them on tissues known to express Kdm8 positively and negatively. Browse below to find the Kdm8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Kdm8? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the KDM8 IHC Guide

Kdm8 Infographic by Boster Bio

All Kdm8 Products

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Specificity

Applications

Price

Anti-KDM8 Antibody Picoband®

Western blot analysis of KDM8 using anti-KDM8 antibody (A08840-2)

Human

ELISA, WB

$370
Cat # A08840-2
100 µg/vial

Anti-JMJD5 KDM8 Antibody

Western blot analysis of JMJD5 in human liver tissue lysate with JMJD5 antibody at (A) 1 and (B) 2 μg/mL

Immunofluorescence of JMJD5 in Rat Liver cells with JMJD5 antibody at 20 μg/mL

Immunohistochemistry of JMJD5 in rat liver tissue with JMJD5 antibody at 2

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$481
Cat # A08840
0.1 mg

Kdm8 Overview

Facts about Bifunctional peptidase and arginyl-hydroxylase JMJD5.

Bifunctional peptidase and arginyl-hydroxylase JMJD5 (Kdm8)

Histone demethylase required for G2/M phase cell cycle progression. Especially demethylates dimethylated'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator.

Regulates expression of CCNA1 (cyclin-A1), leading to modulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated 'Lys-36' (H3K36me3) of histone H3.

Gene Information

Mouse
Gene Name:	Kdm8
Uniprot:	Q9CXT6
Entrez:	77035

Family

Belongs to:

No superfamily

Alternative Names

EC 1.14.11.27; FLJ13798; JmjC domain-containing protein 5; jumonji domain containing 5; Jumonji domain-containing protein 5; KDM8; lysine-specific demethylase 8

Molecular Weight

Mass (kDA):
47.145 kDA

Genomic Context


Mouse

Location:	7\|7 F3
Sequence:	7;

Diseases

Malignant Neoplasms
Neoplasms
Growth Retardation
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Von Hippel-lindau Syndrome

Carcinogenesis

Pathways

Cell Cycle
Demethylation
Cell Proliferation
Histone Demethylation
Methylation
Osteoclast Differentiation
Circadian Rhythm
Histone Lysine Methylation

Cell Cycle Arrest
Chromatin Remodeling

PTMs

Demethylation
Methylation

Hydroxylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Kdm8

References

PMID: 30500822 by Saran A.R., et al. JMJD5 links CRY1 function and proteasomal degradation.