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- Table of Contents
LCAT Antibodies
AND LCAT ELISA kits, LCAT Proteins
Many biological assays use antibodies to detect LCAT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LCAT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LCAT antibodies...
Designing a Western blot for LCAT? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the LCAT Western Blot GuideLCAT Infographic by Boster Bio
All LCAT Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00906
100 μl/vial
Cat # M00906
100 μl/vial
LCAT Overview
Facts about Phosphatidylcholine-sterol acyltransferase.
Phosphatidylcholine-sterol acyltransferase (LCAT)
Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of low and high density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver.
Has a taste for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and affects cerebral spinal fluid (CSF) APOE- and APOA1 levels.
Gene Information
| Human | |
|---|---|
| Gene Name: | LCAT |
| Uniprot: | P04180 |
| Entrez: | 3931 |
Family
| Belongs to: |
|---|
| AB hydrolase superfamily |
Alternative Names
EC 2.3.1.43; lecithin-cholesterol acyltransferasePhospholipid-cholesterol acyltransferase; phosphatidylcholine-sterol acyltransferase
Molecular Weight
Mass (kDA):
49.578 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q22.1 |
| Sequence: | 16; NC_000016.10 (67939750..67944120, complement) |
Tissue Specificity
Detected in blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Detected in cerebral spinal fluid (at protein level) (PubMed:10222237). Detected in liver (PubMed:3797244, PubMed:3458198). Expressed mainly in brain, liver and testes.
Subcellular Localizations
Secreted. Secreted into blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
Diseases
- Lecithin Acyltransferase Deficiency
- Atherosclerosis
- Hyperlipidemia
- Arteriosclerosis
- Hypolipoproteinemias
- Hypercholesterolemia
- Coronary Heart Disease
- Cardiovascular Diseases
- Diabetes Mellitus
- Fish-eye Disease
- Heart Diseases
- Proteinuria Of Undiagnosed Cause
- Liver Diseases
Interacting Proteins
- APOA1
Pathways
- Transport
- Cholesterol Esterification
- Cholesterol Transport
- Reverse Cholesterol Transport
- Cholesterol Efflux
- Secretion
- Excretion
- Lipid Binding
- Pathogenesis
- Cholesterol Homeostasis
- Glycosylation
- Lipid Transport
- Localization
PTMs
- Oxidation
- Glycosylation
- Cleavage
- Acylation
- Reduction
- Acetylation
Research Areas
- Cancer
- Cholesterol Metabolism
- Lipid and Metabolism
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LCAT
bosterbio.com/bosterbio-gene-info-cards/LCAT
References
PMID: 3797244 by McLean J., et al. Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression.
PMID: 3458198 by McLean J., et al. Cloning and expression of human lecithin-cholesterol acyltransferase cDNA.