Serine/threonine-protein kinase LMTK3 (LMTK3)

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly using a PKC-AKT-FOXO3 pathway in which it reduces the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 into the ESR1 promoter and raising ESR1 transcription (PubMed:21602804).

Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity). .