Tyrosine-protein kinase Lyn (LYN)

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an essential role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the circumstance.

Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an essential role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance.