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From the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and complete repression of AgRP transcription) is mediated by STAT3 signaling, whereas different signals regulate NPY and the control of fertility, growth and glucose homeostasis.
|type I cytokine receptor family|
|Sequence:||1; NC_000001.11 (65420652..65641559)|
Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus, but also in skeletal muscle. Detected in fundic and antral epithelial cells of the gastric mucosa (PubMed:19159218). Isoform B and isoform A are expressed by NK cells (at protein level) (PubMed:12504075).
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane.; [Isoform E]: Secreted.
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