Core histone macro-H2A.1 Antibodies

AND MACROH2A1 ELISA kits, Core histone macro-H2A.1 Proteins

Many biological assays use antibodies to detect Core histone macro-H2A.1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Core histone macro-H2A.1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Core histone macro-H2A.1 antibodies...

We validate the specificity of these antibodies to Core histone macro-H2A.1 by testing them on tissues known to express MACROH2A1 positively and negatively. Browse below to find the MACROH2A1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Core histone macro-H2A.1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MACROH2A1 IHC Guide

MACROH2A1 Infographic by Boster Bio

All MACROH2A1 Products

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Applications

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Anti-H2AFY/MACROH2A1 Antibody Picoband®

Western blot analysis of H2AFY/MACROH2A1 using anti-H2AFY/MACROH2A1 antibody (A04635-3)

IHC analysis of H2AFY/MACROH2A1 using anti-H2AFY/MACROH2A1 antibody (A04635-3)

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A04635-3
100 µg/vial

Anti-macroH2A.1 H2AFY Monoclonal Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M04635
100 μl

MACROH2A1 (NM_004893) Human Over-expression Lysate

MACROH2A1 Human Over-expression Lysates NM_001040158

Human

$628
Cat # LS009555
20 µg, 100 µg

MACROH2A1 (NM_004893) Human Recombinant Protein

Coomassie blue staining of purified H2AFY protein

$1062
Cat # PROTO75367
20 µg

MACROH2A1 Overview

Facts about Core histone macro-H2A.1.

MACROH2A1 3D structure. Source: alphafold

Core histone macro-H2A.1 (MACROH2A1)

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes in which it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes compact and wrap DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.

Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Information

Human
Gene Name:	MACROH2A1
Uniprot:	O75367
Entrez:	9555

Family

Belongs to:

No superfamily

Alternative Names

Core histone macro-H2A.1

Molecular Weight

Mass (kDA):
39.617 kDA

Genomic Context


Human

Location:	5q31.1
Sequence:	5; NC_000005.10 (135334381..135401998, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus. Chromosome. Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

Interacting Proteins

ATRX
ERBB2
ERICH2
MAX
TNKS

PTMs

Acetylation
Isopeptide bond

Methylation
Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MACROH2A1

References

PMID: 9714746 by Lee Y., et al. Isolation of cDNA clones encoding human histone macroH2A1 subtypes.

PMID: 9653160 by Mao M., et al. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning.