Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2)

Adapter protein able to interact with various proteins and involved in various biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the next polymerase shifting in translesion DNA synthesis (PubMed:20164194).

Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which has an essential role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893).