MCCC2 Antibodies

AND MCCC2 ELISA kits, MCCC2 Proteins

Many biological assays use antibodies to detect MCCC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MCCC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MCCC2 antibodies...

We validate the specificity of these antibodies to MCCC2 by testing them on tissues known to express MCCC2 positively and negatively. Browse below to find the MCCC2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for MCCC2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MCCC2 IHC Guide

MCCC2 Infographic by Boster Bio

All MCCC2 Products

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Specificity

Applications

Price

Anti-MCCC2 Antibody Picoband®

Western blot analysis of MCCC2 using anti-MCCC2 antibody (A06515-2)

IHC analysis of MCCC2 using anti-MCCC2 antibody (A06515-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A06515-2
100 µg/vial

Anti-MCCC2 Antibody (Center)

MCCC2 Antibody (Center) western blot analysis in NCI-H292 cell line and rat liver tissue lysates (35ug/lane)

Formalin-fixed and paraffin-embedded human hepatocarcinoma with MCCC2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining

Flow cytometric analysis of ATDC5 cells using MCCC2 Antibody (Center) (bottom histogram) compared to a negative control cell (top histogram)

Human, Rat

Flow Cytometry, IHC-P, WB

$299
Cat # A06515-1
80 µl

MCCC2 (NM_022132) Human Over-expression Lysate

Human

$628
Cat # LS064087
20 µg, 100 µg

MCCC2 Overview

Facts about Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial.

MCCC2 3D structure. Source: alphafold

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA into 3-methylglutaconyl-CoA, a crucial step for leucine and isovaleric acid catabolism. .

Gene Information

Human
Gene Name:	MCCC2
Uniprot:	Q9HCC0
Entrez:	64087

Family

Belongs to:

AccD/PCCB family

Alternative Names

3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; MCCase subunit beta; MCCBEC 6.4.1.4; methylcrotonoyl-CoA carboxylase 2 (beta); methylcrotonoyl-Coenzyme A carboxylase 2 (beta); mitochondrial; non-biotin containing subunit of 3-methylcrotonyl-CoA carboxylase

Molecular Weight

Mass (kDA):
61.333 kDA

Genomic Context


Human

Location:	5q13.2
Sequence:	5; NC_000005.10 (71587340..71658706)

Subcellular Localizations

Mitochondrion matrix.

Diseases

Malignant Neoplasm Of Prostate
Neoplasm Metastasis
Malignant Neoplasms
Prostatic Neoplasms
3-methylcrotonyl-coa Carboxylase Deficiency
Cell Invasion
Hereditary Diseases
Metastatic Malignant Neoplasm To The Lymph Node
Prostatic Hyperplasia
Tissue Adhesions
Benign Prostatic Hypertrophy

Lymphatic Metastasis
Neoplasms
Metastatic Prostate Cancer
Asymptomatic Diseases
Deficiency Diseases
Hyperplasia

Pathways

Glycolysis

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCCC2

References

PMID: 11170888 by Gallardo M.E., et al. The molecular basis of 3-methylcrotonylglycinuria, a disorder of leucine catabolism.

PMID: 11181649 by Baumgartner M.R., et al. The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency.