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- Table of Contents
MECP2 Antibodies
AND MECP2 ELISA kits, MECP2 Proteins
Many biological assays use antibodies to detect MECP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MECP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MECP2 antibodies...
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MECP2 Infographic by Boster Bio
All MECP2 Products
Product
Figures
Specificity
Applications
Price
Anti-MECP2 Antibody Picoband®
1 Citations 16 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00047
100 μg/vial
Cat # A00047
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M00047
100 µl
Cat # M00047
100 µl
Human, Monkey, Mouse, Rat
ELISA, IF, IHC, WB
$370
Cat # A00047-1
100 µg/vial
Cat # A00047-1
100 µg/vial
MECP2 Overview
Facts about Methyl-CpG-binding protein 2.
Methyl-CpG-binding protein 2 (MECP2)
Chromosomal protein that binds to methylated DNA. It can bind specifically to one methyl-CpG pair.
It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.
Gene Information
| Human | |
|---|---|
| Gene Name: | MECP2 |
| Uniprot: | P51608 |
| Entrez: | 4204 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AUTSX3; DKFZp686A24160; MeCp-2 protein; mental retardation, X-linked 79; methyl CpG binding protein 2 (Rett syndrome); X-linked 16
Molecular Weight
Mass (kDA):
52.441 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq28 |
| Sequence: | X; NC_000023.11 (154021573..154097731, complement) |
Tissue Specificity
Present in all adult somatic tissues tested.
Subcellular Localizations
Nucleus. Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci.
Diseases
- Rett Syndrome
- Autistic Disorder
- Nervous System Disorder
- Metabolic Bone Disorder
- Epilepsy
- Malignant Neoplasms
- Nervousness
- Neoplasms
- Encephalopathies
- Autism Spectrum Disorders
- Developmental Disabilities
Interacting Proteins
- HIPK2
- Hipk2
- MAX
- Ncor1
- Ncor2
- SIN3A
- SMARCA2
- Tbl1x
- Tbl1xr1
Pathways
- Methylation
- Dna Methylation
- Pathogenesis
- Gene Silencing
- Brain Development
- Chromatin Remodeling
- Localization
- Demethylation
- Histone Deacetylation
- Neurogenesis
- Histone Acetylation
- Histone Modification
- Histone Methylation
PTMs
- Methylation
- Acetylation
- Phosphorylation
- Demethylation
- Deacetylation
- Reduction
Research Areas
- Cancer
- Chromatin Research
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MECP2
bosterbio.com/bosterbio-gene-info-cards/MECP2
References
PMID: 9710633 by Kudo S.; Methyl-CpG-binding protein MeCP2 represses Sp1-activated transcription of the human leukosialin gene when the promoter is methylated.
PMID: 8976388 by Vilain A., et al. Assignment of the gene for methyl-CpG-binding protein 2 (MECP2) to human chromosome band Xq28 by in situ hybridization.
1 Publications of Boster MECP2 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.ijbiomac.2016.12.062, Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast...
*More publications can be found for each product on its corresponding product page