MEGF8 Antibodies

AND MEGF8 ELISA kits, MEGF8 Proteins

Many biological assays use antibodies to detect MEGF8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MEGF8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MEGF8 antibodies...

We validate the specificity of these antibodies to MEGF8 by testing them on tissues known to express MEGF8 positively and negatively. Browse below to find the MEGF8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for MEGF8? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MEGF8 IHC Guide

MEGF8 Infographic by Boster Bio

All MEGF8 Products

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Specificity

Applications

Price

Anti-EGFL4 (R1274) MEGF8 Antibody

Western blot (WB) analysis of EGFL4 (R1274) pAb at 1:500 dilution
Lane1:L02 whole cell lysate(40ug)
Lane2:SGC7901 whole cell lysate(40ug)
Lane3:C6 whole cell lysate(40ug)
Lane4:AML-12 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of EGFL4 (R1274) pAb in paraffin-embedded human breast carcinoma tissue at 1:50

Human, Mouse, Rat

IHC, WB

$405
Cat # A12840-1
100ul

Anti-EGFL4 Antibody

Western Blot analysis of various cells using EGFL4 Polyclonal Antibody

Western blot analysis of lysates from COLO cells, using MEGF8 Antibody

Western blot analysis of the lysates from COLO205 cells using MEGF8 antibody

Human, Mouse, Rat

ELISA, IF, IHC, WB

$399
Cat # A12840
100μl

MEGF8 Overview

Facts about Multiple epidermal growth factor-like domains protein 8.

Multiple epidermal growth factor-like domains protein 8 (MEGF8)

Acts as a negative regulator of hedgehog signaling. .

Gene Information

Human
Gene Name:	MEGF8
Uniprot:	Q7Z7M0
Entrez:	1954

Family

Belongs to:

No superfamily

Alternative Names

C19orf49; chromosome 19 open reading frame 49; EGFL4MGC120684; EGF-like domain-containing protein 4; EGF-like protein 4; EGF-like-domain, multiple 4; Epidermal growth factor-like protein 4; FLJ22365; HBV pre-s2 binding protein 1; KIAA0817; MGC138147; multiple EGF-like domain protein 4; Multiple EGF-like domains protein 8; multiple EGF-like-domains 8; multiple epidermal growth factor-like domains 8; multiple epidermal growth factor-like domains protein 8; SBP1

Molecular Weight

Mass (kDA):
303.1 kDA

Genomic Context


Human

Location:	19q13.2
Sequence:	19; NC_000019.10 (42325635..42378765)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Polysyndactyly
Traumatic Brain Injury
Situs Ambiguus
Congenital Exomphalos
Hernia
Dextrocardia
Congenital Heart Defects
Congenital Heart Disease
Heart Diseases
Brain Diseases
Craniosynostosis
Obesity

Cryptorchidism
Situs Inversus
Autoimmune Syndrome Type Ii, Polyglandular
Tissue Damage
Transposition Of Great Vessels
Brain Injuries

Interacting Proteins

ATXN7
CACNA1A

Pathways

Transport
Transposition
Gastrulation
Phagocytosis
Cell Death
Chromatin Remodeling

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MEGF8

References

PMID: 9693030 by Nakayama M., et al. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening.

PMID: 23063620 by Twigg S.R., et al. Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization.