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- Table of Contents
METTL14 Antibodies
AND METTL14 ELISA kits, METTL14 Proteins
Many biological assays use antibodies to detect METTL14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with METTL14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop METTL14 antibodies...
Designing a Western blot for METTL14? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the METTL14 Western Blot GuideDesigning an IHC experiment for METTL14? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the METTL14 IHC GuideMETTL14 Infographic by Boster Bio
All METTL14 Products
Product
Figures
Specificity
Applications
Price
Anti-METTL14 Antibody Picoband®
3 Citations
Human
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A07389-2
100 μg/vial
Cat # A07389-2
100 μg/vial
Human, Monkey, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M07389-1
100 μl/vial
Cat # M07389-1
100 μl/vial
METTL14 Overview
Facts about N6-adenosine-methyltransferase non-catalytic subunit.
N6-adenosine-methyltransferase non-catalytic subunit (METTL14)
The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and modulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA- binding scaffold that recognizes the substrate as opposed to the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140).
N6-methyladenosine (m6A), which occurs at the 5'-[AG]GAC-3' consensus websites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | METTL14 |
| Uniprot: | Q9HCE5 |
| Entrez: | 57721 |
Family
| Belongs to: |
|---|
| MT-A70-like family |
Alternative Names
EC 2.1.1; EC 2.1.1.-; KIAA1627; KIAA1627methyltransferase-like protein 14; methyltransferase like 14; METTL14
Molecular Weight
Mass (kDA):
52.15 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q26 |
| Sequence: | 4; NC_000004.12 (118685375..118715430) |
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
Interacting Proteins
- METTL3
Pathways
- Cell Proliferation
- Regulation Of Cell Proliferation
PTMs
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/METTL14
bosterbio.com/bosterbio-gene-info-cards/METTL14
References
PMID: 24407421 by Ping X.L., et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.
PMID: 24981863 by Schwartz S., et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.