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- Table of Contents
Mitofusin-1 Antibodies
AND MFN1 ELISA kits, Mitofusin-1 Proteins
Many biological assays use antibodies to detect Mitofusin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mitofusin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mitofusin-1 antibodies...
Designing a Western blot for Mitofusin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MFN1 Western Blot GuideMFN1 Infographic by Boster Bio
All MFN1 Products
Product
Figures
Specificity
Applications
Price
Human
IF, ICC, WB
$370
Cat # M02172-1
100 μg/vial
Cat # M02172-1
100 μg/vial
MFN1 Overview
Facts about Mitofusin-1.
Mitofusin-1 (MFN1)
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125).
It may involve a significant rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are exceptionally dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376).
Gene Information
| Human | |
|---|---|
| Gene Name: | MFN1 |
| Uniprot: | Q8IWA4 |
| Entrez: | 55669 |
Family
| Belongs to: |
|---|
| TRAFAC class dynamin-like GTPase superfamily |
Alternative Names
DKFZp762F247; EC 3.6.5; EC 3.6.5.-; FLJ20693; Fzo homolog; hfzo1; hfzo2; MFN1; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; Mitofusin 1; mitofusin-1; putative transmembrane GTPase; Transmembrane GTPase MFN1
Molecular Weight
Mass (kDA):
84.16 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q26.33 |
| Sequence: | 3; NC_000003.12 (179347709..179394936) |
Tissue Specificity
Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411).
Subcellular Localizations
Mitochondrion outer membrane; Multi-pass membrane protein.; [Isoform 2]: Cytoplasm.
Diseases
- Atrophy
- Optic Atrophy
- Parkinson Disease
- Nerve Degeneration
- Optic Atrophy, Autosomal Dominant
- Neurodegenerative Disorders
- Charcot-marie-tooth Disease
- Malignant Neoplasms
- Peripheral Neuropathy
- Insulin Resistance
- Alzheimer's Disease
- Physiological Stress
Interacting Proteins
- MAVS
- MFN2
Pathways
- Mitochondrial Fusion
- Mitochondrial Fission
- Cell Death
- Membrane Fusion
- Transport
- Autophagy
- Pathogenesis
- Oxidative Phosphorylation
- Rna Interference
- Localization
- Regulation Of Mitochondrial Fusion
- Electron Transport
- Proteolysis
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Cell Biology
- Mitochondrial Fusion Proteins
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MFN1
bosterbio.com/bosterbio-gene-info-cards/MFN1
References
PMID: 11181170 by Santel A., et al. Control of mitochondrial morphology by a human mitofusin.
PMID: 9230308 by Hales K.G., et al. Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.
1 Publications of Boster Mitofusin-1 Antibodies & ELISA Kits
- PubMed ID: 32884840, Jiao Z,Wu Y,Qu S.Fenpropathrin induces degeneration of dopaminergic neurons via ...
*More publications can be found for each product on its corresponding product page