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- Table of Contents
MICU1 Antibodies
AND MICU1 ELISA kits, MICU1 Proteins
Many biological assays use antibodies to detect MICU1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MICU1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MICU1 antibodies...
Designing an IHC experiment for MICU1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MICU1 IHC GuideMICU1 Infographic by Boster Bio
All MICU1 Products
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MICU1 Overview
Facts about Calcium uptake protein 1, mitochondrial.
Calcium uptake protein 1, mitochondrial (MICU1)
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level through its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, based on the concentration of calcium.
MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221).
Gene Information
| Human | |
|---|---|
| Gene Name: | MICU1 |
| Uniprot: | Q9BPX6 |
| Entrez: | 10367 |
Family
| Belongs to: |
|---|
| MICU1 family |
Alternative Names
Allergen Hom s 4; ara CALC; Atopy-related autoantigen CALC; CALCDKFZp564C246; calcium binding atopy-related autoantigen 1; Calcium-binding atopy-related autoantigen 1; MICU1mitochondrial; mitochondrial calcium uptake 1
Molecular Weight
Mass (kDA):
54.351 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q22.1 |
| Sequence: | 10; NC_000010.11 (72367326..72626191, complement) |
Tissue Specificity
Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
Subcellular Localizations
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space.
Diseases
- Dermatitis
- Dermatitis, Atopic
- Inflammation
- Anaphylaxis
- Rhinorrhea
- Malignant Squamous Cell Neoplasm
- Heart Failure
- Diabetes Mellitus
- Carcinoma
Pathways
- Transport
- Cell Death
- Oxidative Phosphorylation
- Rna Interference
- Insulin Secretion
- Anaphylaxis
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MICU1
bosterbio.com/bosterbio-gene-info-cards/MICU1
References
PMID: 9806765 by Natter S., et al. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.
PMID: 16002733 by Aichberger K.J., et al. Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity.