MMP2 Antibodies

72 kDa type IV collagenase (MMP2)

Ubiquitinous metalloproteinase that's involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. Also as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction.

Also cleaves KISS in a Gly-.

Gene Information

Human
Gene Name:	MMP2
Uniprot:	P08253
Entrez:	4313

Family

Belongs to:
peptidase M10A family

Alternative Names

72 kDa gelatinase; CLG4; CLG4A72 kDa type IV collagenase; collagenase type IV-A; EC 3.4.24; EC 3.4.24.24; Gelatinase A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase); matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase); Matrix metalloproteinase-2; matrix metalloproteinase-II; MMP2; MMP-2; MMP-II; MONA; neutrophil gelatinase; TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)

Molecular Weight

Mass (kDA):
73.882 kDA

Genomic Context

Human
Location:	16q12.2
Sequence:	16; NC_000016.10 (55478830..55506691)

Tissue Specificity

Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.

Subcellular Localizations

[Isoform 1]: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.; [Isoform 2]: Cytoplasm. Mitochondrion.

Diseases

• Malignant Neoplasms
• Neoplasms
• Cell Invasion
• Neoplasm Metastasis
• Neoplasm Invasiveness
• Carcinoma
• Tissue Adhesions
• Tumor Angiogenesis
• Inflammation
• Fibrosis
• Malignant Paraganglionic Neoplasm
• Pathologic Neovascularization

• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Lung Neoplasms
• Adenocarcinoma
• Malignant Neoplasm Of Lung
• Infarction
• Myocardial Infarction

Interacting Proteins

• APP
• COL5A1
• PCSK9
• SCUBE3
• TIMP2

Pathways

• Angiogenesis
• Cell Proliferation
• Cell Migration
• Secretion
• Pathogenesis
• Cell Adhesion
• Cell Growth
• Wound Healing
• Cell Cycle
• Localization
• Cell Motility
• Proteolysis
• Tissue Remodeling

• Cell Death
• Regeneration
• Rna Interference
• Inflammatory Response
• Tube Formation
• Reverse Transcription
• Aging

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Nitration
• Reduction
• Oxidation
• Demethylation

• Acetylation
• Carboxylation
• Dephosphorylation
• Acylation
• Glycosylation
• Ubiquitination
• Myristoylation

Research Areas

• Angiogenesis
• Apoptosis
• Cancer
• Cell Biology
• Cellular Markers

• Extracellular Matrix
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMP2

Best Uses Of The MMP2 Marker From Boster Bio

Boster Bio's Multiplex Human MMP2 Chemiluminescent Test is versatile and self-perpetuating. It delivers precise results. Its main applications are markers for tumor metastasis and metastasis detection. It is able to be used to determine human and animal specimens. In addition to identifying tumor cells, it can also be used for other purposes, such as the development of therapeutic drugs.

Multiplex Human MMP2 can be used as a chemiluminescent test

ELISA technology allows for simultaneous measurement of up to five MMPs. This includes Multiplex Human MMP2. MMPs are key enzymes in the cell that cleave extracellular matrix, as well as other cell surfaces receptor proteins, cytokines and Apoptotic binding agents. This chemiluminescent test is built on a recombinant cDNA of human for MMP2.

The chemiluminescent assay demonstrated excellent sensitivity and specificity and met the requirements for precision and accuracy. The Cry1Ab's detection limit was between three and five pg/mL dependent on the format of the assay. The assay was sufficiently sensitive to permit high-throughput analysis. Although there are a few drawbacks to the Multiplex Human MMP2 Chemiluminescent Test, there are many advantages.

Multiplex Human MMP2 is an extremely sensitive and specific chemiluminescent test that determines the amount of MMP2 in clinical samples. The assay is suitable for all types of samples that include serum, blood and plasma. Data collection requires a laser scanner. This test contains a broad human MMPs. It includes 10 human MMPs.

Breast cancer is a hotspot in research. MMPs are linked with breast cancer. A recent study by Jones et al. Jones and co. found that MMP-2 was mostly expressed in tumor cells. However, a tiny amount was also detected in the breast duct and BMs surrounding the acini. A subsequent study by Lebeau et al. MMP-2 and MMP-9 expression was found in 70 patients suffering from breast cancer with infiltrative lesions.

It is a self-perpetuating system

Life is a self-perpetuating system that allows organisms to reproduce to sustain their populations. Self-perpetuation occurs within and between species. In ecosystems, the expansion and reproduction of one species can lead to the reproduction of another and ultimately to the existence of both species. Ecosystems are homeostasis, and the slow-modifying effects of succession cannot be ignored. However, the ideal steady state of any biological system is not attained. This is because sexual reproduction is an imperfect form of self-replication, self-perpetuation and self-replication.

The Flame algorithm was invented over 25 years ago, and has since been employed to design gardens. The results are available in multiple modalities, including a website, a free client-server screensaver, iPad and Android apps immersive projection environments and limited edition works and commercial licensing. With a record of 15 years the algorithm is a first in the field of generative art. It is therefore believed to be one of the most significant components of artificial intelligence.

It is a tumor metastasis marker

Researchers have discovered that saliva has a significant amount of MMP-2. It is a protein involved in cancer pathogenesis. After activation, this protein is typically expressed as a pro MMP-2 that is 72kD. This active form of MMP-2 can be used to detect breast cancer in a non-invasive manner. These results suggest that saliva could be a potential biomarker to diagnose breast cancer.

The overexpression of MMP2 enhances tumor growth in B16 cells. These cells were injected into mice, and tumors were evaluated for weight and volume. In vitro, the growth of tumors was related to MMP2 expression but not MMP9 overexpression. This is in the same vein as other recent findings. MMP2 expression is associated with lymph node metastasis in the prostate cancer. There is also a connection between high levels of MMP-2 as well as MMP-9 in this form of cancer.

The mice that were co-transfected were infected with a plasmid which contained the Mmp-PuroR & GAG. The cells were then cultured in a dish for laboratory use, and the supernatants of the virus were collected and analyzed for the presence of MMP-2. In addition to a tumor-metastasis marker, MMP2 is also believed to play a crucial role in the invasion and metastasis of certain types of cancer.

Researchers are hopeful that irisin an anti-inflammatory drug that targets MMP2 will soon be available for treatment for cancer. MMP2 is part of the matrix metalloproteinases family of proteolytic enzymes. They play a significant role in the metastatic process. The team of researchers also hopes that irisin can stop tumor growth, stimulate an apoptosis process, and trigger anticancer mechanisms in the tumor.

MMP2's effects on immune responses could be due to dysfunctional cross-talk between DC/T cells. This process is not present in Rag2-/ mice. In other words, MMP2 is an endogenous alarmin that regulates the immune response in the tumor microenvironment. MMP2 could also be a marker for metastasis in the tumor.

It is self-perpetuating.

The most significant characteristic of life is their capacity to reproduce and self-perpetuate. This creates a stable population. Ecosystems have the basic property of self-perpetuation. The processes of homeostasis, succession and growth ensure that populations grow and flourish. While the concept of a steady-state may be appealing, it is important to remember that no system can achieve this ideal steady state. Self-replication is not 100% reliable and sexual reproduction, for example is not a self-perpetuating system.

The Flame algorithm was created 25 years ago, and has since been refined to produce gardens. The algorithm can be accessed in multiple modalities that include the web, a free client-server screensaver, iPad and Android apps, immersive projection environments as well as limited edition collectible artworks, and commercial licensing. The algorithm is unique in the category of generative art and has a 15-year track record. It is an essential aspect of artificial life.