This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
MPZL1 Antibodies
AND MPZL1 ELISA kits, MPZL1 Proteins
Many biological assays use antibodies to detect MPZL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MPZL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MPZL1 antibodies...
Previous: CCN4
Next: MAP3K14
MPZL1 Infographic by Boster Bio
All MPZL1 Products
Product
Figures
Specificity
Applications
Price
MPZL1 Overview
Facts about Myelin protein zero-like protein 1.
Myelin protein zero-like protein 1 (MPZL1)
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2.
Is a significant receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA.
Gene Information
| Human | |
|---|---|
| Gene Name: | MPZL1 |
| Uniprot: | O95297 |
| Entrez: | 9019 |
Family
| Belongs to: |
|---|
| myelin P0 protein family |
Alternative Names
FLJ21047; immunoglobulin family transmembrane protein; MPZL1b; myelin protein zero-like 1; myelin protein zero-like protein 1; protein zero related; Protein zero-related; PZR1b; PZRb; PZRPZRa
Molecular Weight
Mass (kDA):
29.082 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q24.2 |
| Sequence: | 1; NC_000001.11 (167721982..167791919) |
Tissue Specificity
Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Charcot-marie-tooth Disease
- Demyelinating Diseases
- Noonan Syndrome
- Polyneuropathy
- Neurological Signs And Symptoms
- Muscle Oedema
- Adipose Tissue Atrophy
- Schizophrenia
- Talipes Cavus
- Atrophy
- Periodic Paralysis (finding)
Interacting Proteins
- PTPN11
Pathways
- Hyperphosphorylation
- Cell Migration
- Blastocyst Formation
- Cell Motility
- Pathogenesis
PTMs
- Phosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPZL1
bosterbio.com/bosterbio-gene-info-cards/MPZL1
References
PMID: 9792637 by Zhao Z.J., et al. Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2.
PMID: 12075424 by Tang D.S., et al. Cloning of human myelin protein zero-like genes by bioinformatics strategy.