Serine/threonine-protein kinase mTOR (MTOR)

Serine/threonine protein kinase that is a fundamental regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly modulates the phosphorylation of at least 800 proteins.

Functions as part of 2 structurally and functionally different signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).