This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
5 Citations 4 Q&As
3 Citations 6 Q&As
4 Citations 17 Q&As
3 Citations 16 Q&As
6 Citations 16 Q&As
Facts about Serine/threonine-protein kinase mTOR.
Functions as part of 2 structurally and functionally different signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).
Human | |
---|---|
Gene Name: | MTOR |
Uniprot: | P42345 |
Entrez: | 2475 |
Belongs to: |
---|
PI3/PI4-kinase family |
EC 2.7.11.1; FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; FLJ44809; FRAP; FRAP1; FRAP1FKBP12-rapamycin complex-associated protein 1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); Mechanistic target of rapamycin; MTOR; RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; Rapamycin target protein 1; RAPT1FKBP-rapamycin associated protein; serine/thr
Mass (kDA):
288.892 kDA
Human | |
---|---|
Location: | 1p36.22 |
Sequence: | 1; NC_000001.11 (11106535..11273497, complement) |
Expressed in numerous tissues, with highest levels in testis.
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm. Nucleus, PML body. Microsome membrane. Lysosome membrane. Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates
This article will discuss the benefits of using the MTOR Marker, Steven Boster's background and some Optimization tips. The MTOR Marker is a unique molecular marker that enables scientists to analyze the metabolic rate of cells. Scientists can submit results for specific samples, species or applications. In addition to this, Boster scientists will be eligible to receive product credits. These benefits are available for any scientist and are applicable to all scientists worldwide.
Steven Boster's history begins in 1993 when he developed his first product. He developed hundreds of primary antibodies and different products for IHC and ELISA. By the late 1990s, he had become the largest catalog antibody company in China. Later, he developed a proprietary ELISA platform, PicoKine(tm). Today, he is best known for the PicoKine line of high-sensitivity ELISA kits.
When it comes to optimizing your ELISA experiments, Boster Bio has a number of optimization tips. These tips can help you achieve the best possible results by removing as many potential sources of error as possible. The first thing to do is prepare your samples. Ideally, your samples will be free of dead cells. Sieve to remove any excess material. Next, select the appropriate antibody concentration and blocking buffer. Then, follow the Boster Bio optimization tips.
PMID: 8008069 by Brown E.J., et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
PMID: 9653645 by Onyango P., et al. Molecular cloning and expression analysis of five novel genes in chromosome 1p36.
*More publications can be found for each product on its corresponding product page