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- Table of Contents
Mettl3 Antibodies
AND Mettl3 ELISA kits, Mettl3 Proteins
Many biological assays use antibodies to detect Mettl3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mettl3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mettl3 antibodies...
Designing a Western blot for Mettl3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the METTL3 Western Blot GuideMettl3 Infographic by Boster Bio
All Mettl3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01758-2
100 μg/vial
Cat # A01758-2
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01758-3
100 μg/vial
Cat # A01758-3
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01758-1
100 μg/vial
Cat # A01758-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01758-1
100 μl/vial
Cat # M01758-1
100 μl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01758-2
20μL, 40μL, 100μL, 200μL
Cat # M01758-2
20μL, 40μL, 100μL, 200μL
Mettl3 Overview
Facts about N6-adenosine-methyltransferase subunit METTL3.
N6-adenosine-methyltransferase subunit METTL3 (Mettl3)
The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and modulates various processes such as the circadian clock, differentiation of embryonic and haematopoietic stem cells, cortical neurogenesis, response to DNA damage, distinction of T-cells and primary miRNA processing (PubMed:25456834, PubMed:24394384, PubMed:25569111, PubMed:28809392, PubMed:28792938, PubMed:28869969, PubMed:28965759). From the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (By similarity).
N6-methyladenosine (m6A), which occurs at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (By similarity). M6A acts as a key regulator of mRNA stability: methylation is completed upon the discharge of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Mettl3 |
| Uniprot: | Q8C3P7 |
| Entrez: | 56335 |
Family
| Belongs to: |
|---|
| MT-A70-like family |
Alternative Names
adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; EC 2.1.1.62; IME4; M6A; methyltransferase like 3; Methyltransferase-like protein 3; MGC4336; mRNA m(6)A methyltransferase; MTA70; MT-A70; N6-adenosine-methyltransferase 70 kDa subunit; Spo8
Molecular Weight
Mass (kDA):
64.616 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 14|14 C2 |
| Sequence: | 14; |
Tissue Specificity
Present in both germ cells and somatic cells during testis development (at protein level) (PubMed:28809392).
Diseases
- Acute Erythroblastic Leukemia
- Puerperal Disorders
- Mood Disorders
- Bipolar Disorder
- Psychotic Disorders
Pathways
- Methylation
- Transport
- Mrna Splicing
- Translation
- Protein Targeting
- Regulation Of Gene Expression
- Endocytosis
- Chromatin Modification
- Sporulation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Mettl3
bosterbio.com/bosterbio-gene-info-cards/Mettl3
References
PMID: 9409616 by Bokar J.A., et al. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.
PMID: 11389549 by Hwang S.-Y., et al. Expression of genes involved in mammalian meiosis during the transition from egg to embryo.