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- Table of Contents
NCOA1 Antibodies
AND NCOA1 ELISA kits, NCOA1 Proteins
Many biological assays use antibodies to detect NCOA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCOA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCOA1 antibodies...
Designing a Western blot for NCOA1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NCOA1 Western Blot GuideDesigning an IHC experiment for NCOA1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NCOA1 IHC GuideNCOA1 Infographic by Boster Bio
All NCOA1 Products
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NCOA1 Overview
Facts about Nuclear receptor coactivator 1.
Nuclear receptor coactivator 1 (NCOA1)
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, like for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs).
Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the significance of such activity remains however unclear.
Gene Information
| Human | |
|---|---|
| Gene Name: | NCOA1 |
| Uniprot: | Q15788 |
| Entrez: | 8648 |
Family
| Belongs to: |
|---|
| SRC/p160 nuclear receptor coactivator family |
Alternative Names
bHLHe42; BHLHE74; Class E basic helix-loop-helix protein 74; EC 2.3.1.48; Hin-2 protein; KAT13A; MGC129719; NCoA-1; nuclear receptor coactivator 1; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160bHLHe74F-SRC-1; SRC-1; SRC1MGC129720; Steroid receptor coactivator 1; steroid receptor coactivator-1
Molecular Weight
Mass (kDA):
156.757 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p23.3 |
| Sequence: | 2; NC_000002.12 (24491254..24770702) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Carcinoma
- Pituitary Diseases
- Endometrial Polyp
- Cell Transformation, Neoplastic
- Hyperplasia
- Liver Carcinoma
- Neoplasm Metastasis
Interacting Proteins
- Asxl1
- ESR1
- Esr1
- KANK2
- Nfkb1
- NR1H3
- NR1H4
- NR1I2
- Nr3c1
- PAGR1
Pathways
- Localization
- Cell Proliferation
- Chromatin Remodeling
- Cell Growth
- Histone Acetylation
- Receptor Transactivation
- Cell Differentiation
- Energy Homeostasis
- Lipid Homeostasis
- Regulation Of Gene Expression
- Rna Interference
- Cell Cycle
- Methylation
PTMs
- Phosphorylation
- Acetylation
- Methylation
- Deacetylation
- Sumoylation
- Ubiquitination
Research Areas
- Cancer
- Chromatin Research
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCOA1
bosterbio.com/bosterbio-gene-info-cards/NCOA1
References
PMID: 8754792 by Takeshita A., et al. Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator.
PMID: 9427757 by Kalkhoven E., et al. Isoforms of steroid receptor coactivator 1 differ in their ability to potentiate transcription by the oestrogen receptor.