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- Table of Contents
NFE2L2 Antibodies
AND NFE2L2 ELISA kits, NFE2L2 Proteins
Many biological assays use antibodies to detect NFE2L2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFE2L2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFE2L2 antibodies...
Designing a Western blot for NFE2L2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NFE2L2 Western Blot GuideNFE2L2 Infographic by Boster Bio
All NFE2L2 Products
Product
Figures
Specificity
Applications
Price
Anti-NFE2L2 Antibody Picoband®
41 Citations
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00078-1
100 μg/vial
Cat # A00078-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # P00078
100 μl
Cat # P00078
100 μl
Anti-NRF2/NFE2L2 Antibody Picoband®
4 Citations
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00078-2
100 μg/vial
Cat # A00078-2
100 μg/vial
Human, Mouse
IP, IF, IHC, ICC, WB
$370
Cat # M00078
100 μl
Cat # M00078
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1408
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1408
1 kit, containing one 96-well plate and all necessary reagents
NFE2L2 Overview
Facts about Nuclear factor erythroid 2-related factor 2.
Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions.
May be involved in the transcriptional activation of genes of this beta-globin audience by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. .
Gene Information
| Human | |
|---|---|
| Gene Name: | NFE2L2 |
| Uniprot: | Q16236 |
| Entrez: | 4780 |
Family
| Belongs to: |
|---|
| bZIP family |
Alternative Names
HEBP1; NFE2L2; NF-E2-related factor 2; NFE2-related factor 2; NRF2 erythroid derived 2, like 2; Nrf2 ihc; Nrf2 immunofluorescence; Nrf2 immunohistochemistry; Nrf2 polyclonal; Nrf2 rat; Nrf2 western blot; Nrf2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2
Molecular Weight
Mass (kDA):
67.827 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q31.2 |
| Sequence: | 2; NC_000002.12 (177230303..177265131, complement) |
Tissue Specificity
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
Subcellular Localizations
Cytoplasm, cytosol. Nucleus. Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:15601839, PubMed:21196497). Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:21196497).
Diseases
- Malignant Neoplasms
- Inflammation
- Neoplasms
- Carcinogenesis
- Carcinoma
- Neurodegenerative Disorders
- Liver Carcinoma
- Cell Transformation, Neoplastic
- Parkinson Disease
- Lung Diseases
- Lung Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Lung
Interacting Proteins
- ATF4
- KEAP1
- MAFG
- MAFK
- Pml
- RARA
- Rara
- TNNT1
- WAC
Pathways
- Cell Death
- Pathogenesis
- Localization
- Response To Oxidative Stress
- Neuroprotection
- Aging
- Cell Proliferation
- Inflammatory Response
- Cell Growth
- Cell Cycle
- Secretion
- Conjugation
- Transport
PTMs
- Phosphorylation
- Ubiquitination
- Oxidation
- Cleavage
- Reduction
- Acetylation
- Methylation
Research Areas
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFE2L2
bosterbio.com/bosterbio-gene-info-cards/NFE2L2
References
PMID: 7937919 by Moi P., et al. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF- E2/AP1 repeat of the beta-globin locus control region.
PMID: 11035812 by Huang H.-C., et al. Regulation of the antioxidant response element by protein kinase C- mediated phosphorylation of NF-E2-related factor 2.
18 Publications of Boster NFE2L2 Antibodies & ELISA Kits
- PubMed ID: 10.3390/molecules23071788, Protection of Anthocyanin from Myrica rubra against Cerebral Ischemia-Reperfusio...
- PubMed ID: 10.3389/fnagi.2020.00226, Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by ...
- PubMed ID: 10.1186/s13578-021-00734-x, Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acu...
- PubMed ID: 10.1111/jphp.13343, Modulation of non‐steroidal anti‐inflammatory drug‐induced, ER stress‐me...
- PubMed ID: 10.1039/C6RA14831J, Individual and combined antioxidant effects of ginsenoside F2 and cyanidin-3-O-g...
- PubMed ID: 10.1016/j.toxlet.2017.07.215, MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nr...
- PubMed ID: 10.1016/j.bbrc.2017.08.089, Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis ...
- PubMed ID: 10.1007/s12013-019-00890-5, Grape Seed Procyanidins Attenuates Cisplatin-induced Human Embryonic Renal Cell ...
- PubMed ID: 10.1002/tox.22374, Protection of Nrf2 against arsenite‐induced oxidative damage is regulated by t...
- PubMed ID: 31026730, Xin X,Yao D,Zhang K,Han S,Liu D,Wang H,Liu X,Li G,Huang J,Wang J.Protective effe...
- PubMed ID: 34116043, Chen M,Wang Z,Zhou W,Lu C,Ji T,Yang W,Jin Z,Tian Y,Lei W,Wu S,Fu Q,Wu Z,Wu X,Han...
- PubMed ID: -, Huanyue Cui,Xueying Liu,Jin Zhang,Ke Zhang,Dahong Yao,Shi Dong,Shushu Feng,Lu Ya...
- PubMed ID: 33359640, Li D,Bai X,Jiang Y,Cheng Y.Butyrate alleviates PTZ-induced mitochondrial dysfunc...
- PubMed ID: 32030632, Li X,Zuo C,Sun D,Zhao T,Zhang Z.Arsenite Increases Linc-ROR in Human Bronchial E...
- PubMed ID: 27529235, Protective effects of berberine on renal injury in streptozotocin (STZ)-induced ...
- PubMed ID: 28939896, miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing ...
- PubMed ID: 27774770, Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the...
- PubMed ID: 27484042, The protective role of vitamin D3 in a murine model of asthma via the suppressio...
*More publications can be found for each product on its corresponding product page