Homeobox protein Nkx-2.2 Antibodies

AND NKX2-2 ELISA kits, Homeobox protein Nkx-2.2 Proteins

Many biological assays use antibodies to detect Homeobox protein Nkx-2.2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Homeobox protein Nkx-2.2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Homeobox protein Nkx-2.2 antibodies...

We validate the specificity of these antibodies to Homeobox protein Nkx-2.2 by testing them on tissues known to express NKX2-2 positively and negatively. Browse below to find the NKX2-2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NKX2-2 Infographic by Boster Bio

All NKX2-2 Products

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Anti-Homeobox protein Nkx-2.2 NKX2-2 Antibody

Western blot analysis of NKX2-2 in rat kidney tissue lysate with NKX2-2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide

Immunohistochemistry of NKX2-2 in human kidney tissue with NKX2-2 antibody at 2

Immunofluorescence of NKX2-2 in human kidney tissue with NKX2-2 antibody at 20 μg/mL

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$481
Cat # A04740
0.1 mg

Anti-NKX2.2 Rabbit Monoclonal Antibody

Immunohistochemical analysis of paraffin-embedded human pancreas, using NKX2

Human, Mouse, Rat

IF, IHC, ICC

$370
Cat # M04740-1
100 μl/vial

Nkx2.2 (NKX2-2) (NM_002509) Human Over-expression Lysate

Human

$628
Cat # LS004821
20 µg, 100 µg

Anti-NKX2-2 Antibody

Human, Mouse, Rat

IF, IHC, ICC

$370
Cat # A04740-2
100 μg/vial

NKX2-2 Overview

Facts about Homeobox protein Nkx-2.2.

NKX2-2 3D structure. Source: alphafold

Homeobox protein Nkx-2.2 (NKX2-2)

Transcriptional activator involved in the creation of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance.

Binds to elements within the NEUROD1 promoter (By similarity). .

Gene Information

Human
Gene Name:	NKX2-2
Uniprot:	O95096
Entrez:	4821

Family

Belongs to:

NK-2 homeobox family

Alternative Names

Homeobox protein NK-2 homolog B; NK-2 (Drosophila) homolog B; NK2 homeobox 2; NK2 transcription factor related, locus 2 (Drosophila); NK2 transcription factor related, locus 2; NK2 transcription factor-like protein B; NKX2.2; NKX2.2homeobox protein Nkx-2.2; NKX2B; NKX2BNK-2 homolog B

Molecular Weight

Mass (kDA):
30.133 kDA

Genomic Context


Human

Location:	20p11.22
Sequence:	20; NC_000020.11 (21511010..21514064, complement)

Subcellular Localizations

Nucleus.

Diseases

Parkinson Disease
Neoplasms
Nervousness
Diabetes Mellitus
Lymphohistiocytosis, Hemophagocytic
Mental Disorders
Diabetes Mellitus, Non-insulin-dependent
Neoplasm Metastasis
Fracture Of First Cervical Vertebra
Malignant Neoplasm Of Breast
Glioma
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
Insulin Resistance

Tumor Angiogenesis
Malignant Neoplasms
Mammary Neoplasms
Congenital Absence
Nervous System Disorder
Glioblastoma
Oligodendroglioma

Pathways

Pancreas Development
Methylation
Dna Methylation
Cell Cycle
Gliogenesis
Developmental Process
Cell Development
Insulin Secretion
Cell Fate Commitment
Neurogenesis
Neuron Development
Histone Modification

Cell Maturation
Glucose Homeostasis
Endocrine Pancreas Development
Cell Differentiation
Angiogenesis
Oligodendrocyte Development
Secretion

PTMs

Methylation

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NKX2-2

References

PMID: 9703340 by Furuta H., et al. Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese.