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Homeobox protein Nkx-3.1 Antibodies
AND NKX3-1 ELISA kits, Homeobox protein Nkx-3.1 Proteins
Many biological assays use antibodies to detect Homeobox protein Nkx-3.1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Homeobox protein Nkx-3.1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Homeobox protein Nkx-3.1 antibodies...
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NKX3-1 Overview
Facts about Homeobox protein Nkx-3.1.
Homeobox protein Nkx-3.1 (NKX3-1)
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an essential role in normal prostate growth, regulating proliferation of glandular epithelium and in the creation of ducts in prostate.
Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. .
Gene Information
| Human | |
|---|---|
| Gene Name: | NKX3-1 |
| Uniprot: | Q99801 |
| Entrez: | 4824 |
Family
| Belongs to: |
|---|
| NK-3 homeobox family |
Alternative Names
BAPX2; BAPX2homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A; NK homeobox (Drosophila), family 3, A; NK3 homeobox 1; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1 (Drosophila); NK3 transcription factor related, locus 1; NKX3.1; NKX3.1NKX3; NKX3-1; NKX3A; NKX3ANK homeobox, family 3, A
Molecular Weight
Mass (kDA):
26.35 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.2 |
| Sequence: | 8; NC_000008.11 (23678693..23682938, complement) |
Tissue Specificity
Highly expressed in the prostate and, at a lower level, in the testis.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Neoplasms
- Carcinoma
- Carcinogenesis
- Prostatic Intraepithelial Neoplasias
- Cell Transformation, Neoplastic
- Intraepithelial Neoplasia
- Adenocarcinoma
- Hyperplasia
- Neoplasm Metastasis
Interacting Proteins
- EHMT2
- TOP1
Pathways
- Cell Proliferation
- Cell Growth
- Localization
- Cell Cycle
- Epithelial Cell Proliferation
- Aging
- Cell Differentiation
- Pathogenesis
- Rna Interference
- Secretion
- Stem Cell Maintenance
- Histone Acetylation
- Chromatin Remodeling
PTMs
- Phosphorylation
- Acetylation
Research Areas
- Cancer
- Chromatin Research
- Prostate Cancer
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NKX3-1
bosterbio.com/bosterbio-gene-info-cards/NKX3-1
References
PMID: 9226374 by He W.-W., et al. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer.
PMID: 9537602 by Prescott J.L., et al. Isolation and androgen regulation of the human homeobox cDNA, NKX3.1.