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- Table of Contents
1 Citations 6 Q&As
Facts about Nucleotide-binding oligomerization domain-containing protein 1.
Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system together with ARHGEF2 for the detection of parasitic effectors during cell invasion by pathogens.
| Human | |
|---|---|
| Gene Name: | NOD1 |
| Uniprot: | Q9Y239 |
| Entrez: | 10392 |

| Belongs to: |
|---|
| No superfamily |

CARD4; CARD4NLR family, CARD domain containing 1; caspase recruitment domain family, member 4; Caspase recruitment domain-containing protein 4; CLR7.1; NLRC1; NOD1; nucleotide-binding oligomerization domain containing 1; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domaincontaining 1; nucleotide-binding oligomerization domain-containing protein 1
Mass (kDA):
107.691 kDA

| Human | |
|---|---|
| Location: | 7p14.3 |
| Sequence: | 7; NC_000007.14 (30424527..30478866, complement) |
Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.






PMID: 10224040 by Bertin J., et al. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB.
PMID: 10329646 by Inohara N., et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor- kappaB.
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