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- Table of Contents
Nostrin Antibodies
AND NOSTRIN ELISA kits, Nostrin Proteins
Many biological assays use antibodies to detect Nostrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nostrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nostrin antibodies...
Designing an IHC experiment for Nostrin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NOSTRIN IHC GuideNOSTRIN Infographic by Boster Bio
All NOSTRIN Products
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Specificity
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NOSTRIN Overview
Facts about Nostrin.
Nostrin (NOSTRIN)
Multivalent adapter protein which might decrease NOS3 activity by inducing its translocation from the plasma membrane. .
Gene Information
| Human | |
|---|---|
| Gene Name: | NOSTRIN |
| Uniprot: | Q8IVI9 |
| Entrez: | 115677 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BM247 homolog; DaIP2; endothelial nitric oxide synthase traffic inducer; ENOS traffic inducer; eNOS-trafficking inducer; Nitric oxide synthase traffic inducer; nitric oxide synthase traffickerMGC20702; nitric oxide synthase trafficking; nostrin; ortholog of mouse disabled 2 interacting proein 2
Molecular Weight
Mass (kDA):
57.66 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q24.3 |
| Sequence: | 2; NC_000002.12 (168786539..168865514) |
Tissue Specificity
Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over- expressed in placenta from women with pre-eclampsia (at protein level).
Subcellular Localizations
[Isoform 1]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; [Isoform 3]: Nucleus.
Diseases
- Hypertensive Disease
- Pre-eclampsia
- Inflammation
- Hepatitis, Alcoholic
- Coronary Heart Disease
- Otitis Media
- Hypoxia
- Teratocarcinoma
- Sequelae Aspects
- Otitis Media Acute
- Hypertension Induced By Pregnancy
- Hypokinesia
- Cardiovascular Diseases
Interacting Proteins
- DNM1
- FGFR1
- NOS3
- Wasl
Pathways
- Localization
- Pathogenesis
- Cell Adhesion
- Endocytosis
- Nuclear Export
- Spermatogenesis
- Senescence
- Cell Differentiation
- Membrane Fission
PTMs
- Nitration
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NOSTRIN
bosterbio.com/bosterbio-gene-info-cards/NOSTRIN
References
PMID: 12446846 by Zimmermann K., et al. NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase.
PMID: 11489260 by Kirsch T., et al. Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats.