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Homeobox protein Nkx-3.1 Antibodies
AND NKX3-1 ELISA kits, Homeobox protein Nkx-3.1 Proteins
Many biological assays use antibodies to detect Homeobox protein Nkx-3.1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Homeobox protein Nkx-3.1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Homeobox protein Nkx-3.1 antibodies...
Designing a Western blot for Homeobox protein Nkx-3.1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NKX3-1 Western Blot GuideDesigning an IHC experiment for Homeobox protein Nkx-3.1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NKX3-1 IHC GuideNKX3-1 Infographic by Boster Bio
All NKX3-1 Products
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NKX3-1 Overview
Facts about Homeobox protein Nkx-3.1.
Homeobox protein Nkx-3.1 (NKX3-1)
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an essential role in normal prostate growth, regulating proliferation of glandular epithelium and in the creation of ducts in prostate.
Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. .
Gene Information
| Human | |
|---|---|
| Gene Name: | NKX3-1 |
| Uniprot: | Q99801 |
| Entrez: | 4824 |
Family
| Belongs to: |
|---|
| NK-3 homeobox family |
Alternative Names
BAPX2; BAPX2homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A; NK homeobox (Drosophila), family 3, A; NK3 homeobox 1; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1 (Drosophila); NK3 transcription factor related, locus 1; NKX3.1; NKX3.1NKX3; NKX3-1; NKX3A; NKX3ANK homeobox, family 3, A
Molecular Weight
Mass (kDA):
26.35 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.2 |
| Sequence: | 8; NC_000008.11 (23678693..23682938, complement) |
Tissue Specificity
Highly expressed in the prostate and, at a lower level, in the testis.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Neoplasms
- Carcinoma
- Carcinogenesis
- Prostatic Intraepithelial Neoplasias
- Cell Transformation, Neoplastic
- Intraepithelial Neoplasia
- Adenocarcinoma
- Hyperplasia
- Neoplasm Metastasis
Interacting Proteins
- EHMT2
- TOP1
Pathways
- Cell Proliferation
- Cell Growth
- Localization
- Cell Cycle
- Epithelial Cell Proliferation
- Aging
- Cell Differentiation
- Pathogenesis
- Rna Interference
- Secretion
- Stem Cell Maintenance
- Histone Acetylation
- Chromatin Remodeling
PTMs
- Phosphorylation
- Acetylation
Research Areas
- Cancer
- Chromatin Research
- Prostate Cancer
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NKX3-1
bosterbio.com/bosterbio-gene-info-cards/NKX3-1
References
PMID: 9226374 by He W.-W., et al. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer.
PMID: 9537602 by Prescott J.L., et al. Isolation and androgen regulation of the human homeobox cDNA, NKX3.1.