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- Table of Contents
OAS2 Antibodies
AND OAS2 ELISA kits, OAS2 Proteins
Many biological assays use antibodies to detect OAS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OAS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OAS2 antibodies...
Designing a Western blot for OAS2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the OAS2 Western Blot GuideDesigning an IHC experiment for OAS2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the OAS2 IHC GuideOAS2 Infographic by Boster Bio
All OAS2 Products
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OAS2 Overview
Facts about 2'-5'-oligoadenylate synthase 2.
2'-5'-oligoadenylate synthase 2 (OAS2)
Interferon-induced, dsRNA-activated antiviral receptor that plays a vital role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'- 5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059).
Activation of RNASEL leads to degradation of cellular as well as viral RNA, leading to the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or another antiviral pathway independent of RNASEL (PubMed:21142819).
Gene Information
| Human | |
|---|---|
| Gene Name: | OAS2 |
| Uniprot: | P29728 |
| Entrez: | 4939 |
Family
| Belongs to: |
|---|
| 2-5A synthase family |
Alternative Names
(2-5')oligo(A) synthase 2; (2'-5')oligo(A) synthetase 2; (2-5')oligo(A) synthetase 2; 2'5' oligoadenylate synthetase 2; 2-5A synthase 2; 2-5A synthetase 2; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2 (69-71 kD); 2'-5'-oligoadenylate synthetase 2, 69/71kDa; EC 2.7.7; EC 2.7.7.-; MGC78578; OAS2; p69 OAS / p71 OAS; p69OAS / p71OAS
Molecular Weight
Mass (kDA):
82.431 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.13 |
| Sequence: | 12; NC_000012.12 (112978466..113011723) |
Subcellular Localizations
Cytoplasm. Cytoplasm, perinuclear region.
Diseases
- Virus Diseases
- Hepatitis
- Hepatitis C
- Hepatitis C, Chronic
- Malignant Neoplasms
- Hepatitis, Chronic
- Infective Disorder
- Hepatitis B
- Carcinoma
- Fibrosis
- Lupus Erythematosus, Systemic
- Dysequilibrium Syndrome
- Autoimmune Diseases
Interacting Proteins
- CLK3
Pathways
- Immune Response
- Pathogenesis
- Cell Proliferation
- Innate Immune Response
- Secretion
- Response To Lipopolysaccharide
- Cell Adhesion
- Gene Silencing
- Response To Hypoxia
- Tube Formation
- Lymphangiogenesis
- Endothelial Cell Proliferation
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OAS2
bosterbio.com/bosterbio-gene-info-cards/OAS2
References
PMID: 1577824 by Marie I., et al. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.
PMID: 11986302 by Sarkar S.N., et al. Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase.