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- Table of Contents
P2X purinoceptor 7 Antibodies
AND P2RX7 ELISA kits, P2X purinoceptor 7 Proteins
Many biological assays use antibodies to detect P2X purinoceptor 7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with P2X purinoceptor 7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop P2X purinoceptor 7 antibodies...
Designing a Western blot for P2X purinoceptor 7? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the P2RX7 Western Blot GuideP2RX7 Infographic by Boster Bio
All P2RX7 Products
Product
Figures
Specificity
Applications
Price
Anti-P2X7/P2RX7 Antibody Picoband®
3 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01208-3
100 μg/vial
Cat # A01208-3
100 μg/vial
Anti-P2X purinoceptor 7 P2RX7 Antibody Picoband®
3 Citations
Human, Mouse, Rat
WB
$370
Cat # PA2129
100 μg/vial
Cat # PA2129
100 μg/vial
P2RX7 Overview
Facts about P2X purinoceptor 7.
P2X purinoceptor 7 (P2RX7)
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules.
Could operate in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).
Gene Information
| Human | |
|---|---|
| Gene Name: | P2RX7 |
| Uniprot: | Q99572 |
| Entrez: | 5027 |
Family
| Belongs to: |
|---|
| P2X receptor family |
Alternative Names
ATP receptor; MGC20089; P2RX7; P2X purinoceptor 7; P2X7; P2X7P2X7 receptor; P2X7R; P2Z receptor; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A; Purinergic receptor
Molecular Weight
Mass (kDA):
68.585 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.31 |
| Sequence: | 12; NC_000012.12 (121132819..121188032) |
Tissue Specificity
Widely expressed with highest levels in brain and immune tissues.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Inflammation
- Pain
- Nervousness
- Chronic Lymphocytic Leukemia
- Leukemia
- Malignant Neoplasms
- Lymphoid Leukemia
- Tuberculosis
- Depressive Disorder
- Bipolar Disorder
- Neoplasms
- Mood Disorders
- Arthritis
Pathways
- Cell Death
- Secretion
- Localization
- Pathogenesis
- Immune Response
- Response To Atp
- Inflammatory Response
- Cell Proliferation
- Transport
- Cytokine Production
- Synaptic Transmission
- Membrane Depolarization
- Innate Immune Response
PTMs
- Phosphorylation
- Cleavage
- Ribosylation
- Dephosphorylation
- Glycosylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/P2RX7
bosterbio.com/bosterbio-gene-info-cards/P2RX7
References
PMID: 9038151 by Rassendren F., et al. The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA.
PMID: 9826911 by Buell G.N., et al. Gene structure and chromosomal localization of the human P2X7 receptor.
2 Publications of Boster P2X purinoceptor 7 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.clineuro.2017.04.012, Increased expression of P2X7 receptor in peripheral blood mononuclear cells corr...
- PubMed ID: 32783373, Zou Z,Wang Q,Zhou M,Li W,Zheng Y,Li F,Zheng S,He Z.Protective effects of P2X7R a...
*More publications can be found for each product on its corresponding product page